Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. PeledIsrael Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.

Original languageEnglish (US)
Pages (from-to)2267180
Number of pages1
JournalGut Microbes
Issue number2
StatePublished - Dec 1 2023


  • IBD
  • Immunity
  • graft rejection
  • graft-versus-host disease
  • gut microbiome
  • gut-brain-axis
  • infection
  • micronutrition
  • mitochondria
  • oral microbiome
  • posttraumatic stress disorder
  • virome
  • vitamin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Gastroenterology
  • Infectious Diseases
  • Microbiology


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