Modifying matrix remodeling to prevent heart failure

K. Y. Deleon, A. Yabluchanskiy, M. D. Winniford, R. A. Lange, R. J. Chilton, M. L. Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

Original languageEnglish (US)
Title of host publicationCardiac Regeneration and Repair
PublisherElsevier Ltd
Pages41-60
Number of pages20
Volume1
ISBN (Print)9780857096586
DOIs
StatePublished - Feb 1 2014

    Fingerprint

Keywords

  • Cardiac remodeling
  • Extracellular matrix
  • Heart failure
  • Matrix metalloproteinases
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Deleon, K. Y., Yabluchanskiy, A., Winniford, M. D., Lange, R. A., Chilton, R. J., & Lindsey, M. L. (2014). Modifying matrix remodeling to prevent heart failure. In Cardiac Regeneration and Repair (Vol. 1, pp. 41-60). Elsevier Ltd. https://doi.org/10.1533/9780857096708.1.41