Modifying matrix remodeling to prevent heart failure

K. Y. Deleon; A. Yabluchanskiy; M. D. Winniford; R. A. Lange; R. J. Chilton; M. L. Lindsey

doi:10.1533/9780857096708.1.41

Modifying matrix remodeling to prevent heart failure

K. Y. Deleon, A. Yabluchanskiy, M. D. Winniford, R. A. Lange, R. J. Chilton, M. L. Lindsey

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

Original language	English (US)
Title of host publication	Pathology and Therapies
Publisher	Elsevier Ltd
Pages	41-60
Number of pages	20
Volume	1
ISBN (Print)	9780857096586
DOIs	https://doi.org/10.1533/9780857096708.1.41
State	Published - Feb 2014

Keywords

Cardiac remodeling
Extracellular matrix
Heart failure
Matrix metalloproteinases
Myocardial infarction

ASJC Scopus subject areas

General Dentistry
General Medicine

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10.1533/9780857096708.1.41

Cite this

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title = "Modifying matrix remodeling to prevent heart failure",

abstract = "In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.",

keywords = "Cardiac remodeling, Extracellular matrix, Heart failure, Matrix metalloproteinases, Myocardial infarction",

author = "Deleon, {K. Y.} and A. Yabluchanskiy and Winniford, {M. D.} and Lange, {R. A.} and Chilton, {R. J.} and Lindsey, {M. L.}",

note = "Funding Information: We acknowledge support from AHA for POST14350034 and NIH/NHLBI T32 HL007446to KYD-P, from the Rapoport Foundation to RAL, and from NIH/NHLBI for the HHSN 268201000036C (N01-HV-00244) San Antonio Cardiovascular Proteomics Center, HL075360, and HL051971, and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5101BX000505 to MLL.",

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AU - Deleon, K. Y.

AU - Yabluchanskiy, A.

AU - Winniford, M. D.

AU - Lange, R. A.

AU - Chilton, R. J.

AU - Lindsey, M. L.

N1 - Funding Information: We acknowledge support from AHA for POST14350034 and NIH/NHLBI T32 HL007446to KYD-P, from the Rapoport Foundation to RAL, and from NIH/NHLBI for the HHSN 268201000036C (N01-HV-00244) San Antonio Cardiovascular Proteomics Center, HL075360, and HL051971, and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5101BX000505 to MLL.

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Y1 - 2014/2

N2 - In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

AB - In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

KW - Cardiac remodeling

KW - Extracellular matrix

KW - Heart failure

KW - Matrix metalloproteinases

KW - Myocardial infarction

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PB - Elsevier Ltd

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Modifying matrix remodeling to prevent heart failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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