Abstract
One tenth of the LD50 as a single dose of various N-nitroso compounds (N-nitrosodimethylamine; NDMA, N-nitrosodiethylamine; NDEA, N- nitrosoethylpropylamine; NEPA, N-nitrosodipropylamine; NDPA, N- nitrosomethylethylamine; NMEA, N-nitroso-methylbutylamine; NMBA and N- nitrosoethylbutylamine; NEBA) was administrated into male mice. This dose markedly increased the hepatic contents of cytochrome P450 and cytochrome b5 and activities of NADPH-cytochrome c reductase and aryl hydrocarbon hydroxylase (AHH). The highest increase in the activity of cytochrome P450 (+142% relative to the control value) was shown in animals treated with either N-nitrosoethylpropylamine or N-nitrosodiethylamine. On the other hand, the lowest increase in the activity (+16%) was revealed in animals treated with N-nitrosodimethylamine (not significant compared to the control value). Cytochrome b5 content was increased by 190% of the control value in mice treated with N-nitrosomethylbutylamine, while N-nitrosodibutylamine induced the lowest increase (+20%). The maximum increase (+182%) in the activity of aryl hydrocarbon hydroxylase was shown in animals which received N- nitrosomethylbutylamine, while the lowest increase (+23%) in animals which received N-nitrosodiethylamine. The activity of hepatic AHH was also increased above the control value in animals treated with NDMA, NEBA NDPA, NMEA and NDBA by 138, 98, 90, 89 and 69%, respectively. Identically, NADPH- cytochrome c reductase activity was increased in animals which received NEPA, NMBA, NDMA, NMEA, NDPA, NEBA and NDEA by 202, 150, 110, 95, 94, 77 and 37%, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 965-969 |
| Number of pages | 5 |
| Journal | Oncology Reports |
| Volume | 5 |
| Issue number | 4 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Aryl hydrocarbon hydroxylase
- Cytochrome P450
- N-nitroso compounds
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Modifications in the carcinogen-metabolizing capacity of mouse liver treated with N-nitroso compounds. / Habib, Samy L; Badawi, Alaa F.; Aweny, Hala A.; Mostafa, Mostafa H.
In: Oncology Reports, Vol. 5, No. 4, 1998, p. 965-969.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modifications in the carcinogen-metabolizing capacity of mouse liver treated with N-nitroso compounds
AU - Habib, Samy L
AU - Badawi, Alaa F.
AU - Aweny, Hala A.
AU - Mostafa, Mostafa H.
PY - 1998
Y1 - 1998
N2 - One tenth of the LD50 as a single dose of various N-nitroso compounds (N-nitrosodimethylamine; NDMA, N-nitrosodiethylamine; NDEA, N- nitrosoethylpropylamine; NEPA, N-nitrosodipropylamine; NDPA, N- nitrosomethylethylamine; NMEA, N-nitroso-methylbutylamine; NMBA and N- nitrosoethylbutylamine; NEBA) was administrated into male mice. This dose markedly increased the hepatic contents of cytochrome P450 and cytochrome b5 and activities of NADPH-cytochrome c reductase and aryl hydrocarbon hydroxylase (AHH). The highest increase in the activity of cytochrome P450 (+142% relative to the control value) was shown in animals treated with either N-nitrosoethylpropylamine or N-nitrosodiethylamine. On the other hand, the lowest increase in the activity (+16%) was revealed in animals treated with N-nitrosodimethylamine (not significant compared to the control value). Cytochrome b5 content was increased by 190% of the control value in mice treated with N-nitrosomethylbutylamine, while N-nitrosodibutylamine induced the lowest increase (+20%). The maximum increase (+182%) in the activity of aryl hydrocarbon hydroxylase was shown in animals which received N- nitrosomethylbutylamine, while the lowest increase (+23%) in animals which received N-nitrosodiethylamine. The activity of hepatic AHH was also increased above the control value in animals treated with NDMA, NEBA NDPA, NMEA and NDBA by 138, 98, 90, 89 and 69%, respectively. Identically, NADPH- cytochrome c reductase activity was increased in animals which received NEPA, NMBA, NDMA, NMEA, NDPA, NEBA and NDEA by 202, 150, 110, 95, 94, 77 and 37%, respectively.
AB - One tenth of the LD50 as a single dose of various N-nitroso compounds (N-nitrosodimethylamine; NDMA, N-nitrosodiethylamine; NDEA, N- nitrosoethylpropylamine; NEPA, N-nitrosodipropylamine; NDPA, N- nitrosomethylethylamine; NMEA, N-nitroso-methylbutylamine; NMBA and N- nitrosoethylbutylamine; NEBA) was administrated into male mice. This dose markedly increased the hepatic contents of cytochrome P450 and cytochrome b5 and activities of NADPH-cytochrome c reductase and aryl hydrocarbon hydroxylase (AHH). The highest increase in the activity of cytochrome P450 (+142% relative to the control value) was shown in animals treated with either N-nitrosoethylpropylamine or N-nitrosodiethylamine. On the other hand, the lowest increase in the activity (+16%) was revealed in animals treated with N-nitrosodimethylamine (not significant compared to the control value). Cytochrome b5 content was increased by 190% of the control value in mice treated with N-nitrosomethylbutylamine, while N-nitrosodibutylamine induced the lowest increase (+20%). The maximum increase (+182%) in the activity of aryl hydrocarbon hydroxylase was shown in animals which received N- nitrosomethylbutylamine, while the lowest increase (+23%) in animals which received N-nitrosodiethylamine. The activity of hepatic AHH was also increased above the control value in animals treated with NDMA, NEBA NDPA, NMEA and NDBA by 138, 98, 90, 89 and 69%, respectively. Identically, NADPH- cytochrome c reductase activity was increased in animals which received NEPA, NMBA, NDMA, NMEA, NDPA, NEBA and NDEA by 202, 150, 110, 95, 94, 77 and 37%, respectively.
KW - Aryl hydrocarbon hydroxylase
KW - Cytochrome P450
KW - N-nitroso compounds
UR - http://www.scopus.com/inward/record.url?scp=0031842004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031842004&partnerID=8YFLogxK
M3 - Article
C2 - 9625856
AN - SCOPUS:0031842004
VL - 5
SP - 965
EP - 969
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 4
ER -