Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat

J. W. Buckle, P. W. Nathanielsz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short term infusions of theophylline, dibutyryl cyclic AMP and 8 bromo cyclic GMP were investigated. All 3 compounds caused a decrease in oxytoxin induced, prostaglandin F2(α) induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalJournal of Endocrinology
Volume66
Issue number3
DOIs
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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