Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short term infusions of theophylline, dibutyryl cyclic AMP and 8 bromo cyclic GMP were investigated. All 3 compounds caused a decrease in oxytoxin induced, prostaglandin F2(α) induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism