Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat

J. W. Buckle; P. W. Nathanielsz

doi:10.1677/joe.0.0660339

Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat

J. W. Buckle, P. W. Nathanielsz

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short term infusions of theophylline, dibutyryl cyclic AMP and 8 bromo cyclic GMP were investigated. All 3 compounds caused a decrease in oxytoxin induced, prostaglandin F₂(α) induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.

Original language	English (US)
Pages (from-to)	339-347
Number of pages	9
Journal	Journal of Endocrinology
Volume	66
Issue number	3
DOIs	https://doi.org/10.1677/joe.0.0660339
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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AB - Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short term infusions of theophylline, dibutyryl cyclic AMP and 8 bromo cyclic GMP were investigated. All 3 compounds caused a decrease in oxytoxin induced, prostaglandin F2(α) induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.

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