Modification of maternal and fetal oxygenation with the use of tracheal gas infusion

Robin D. Gleed, E. Robin Poore, Jorge P. Figueroa, Peter W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A new technique is described for producing changes in fetal blood gases in the chronically instrumented pregnant sheep. Gas mixtures were infused directly into the maternal trachea. Maternal and fetal carotid arterial blood gases and pH were measured. Air infusion at 16 L · min-1 produced no change. Oxygen infusion caused significant increases in maternal PaO2 at 2 L·min-1 and in fetal PaO2 at 4 L·min-1. Nitrogen infusion significantly decreased maternal and fetal PaO2 at 4 L·min-1. During 4 L·min-1 oxygen infusion, maternal PaO2 rose rapidly to plateau at 314 ± 47 mm Hg at 4 minutes and fetal PaO2 rose to plateau at 28.7 ± 2.8 mm Hg after 7 to 8 minutes. Maternal PaO2 fell to 56.4 ± 4.3 mm Hg during nitrogen infusion (4 L·min-1) while fetal PaO2 fell to 15.9 ± 1.8 mm Hg. Continuous infusion for 5- to 6-hour periods produced a consistent rise in maternal PaO2 during oxygen infusion and a consistent decrease during nitrogen infusion. Tracheal infusion of gases can be used to change maternal and fetal PaO2 rapidly and predictably.

Original languageEnglish (US)
Pages (from-to)429-435
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
StatePublished - Aug 1986
Externally publishedYes


  • Fetus
  • fetal monitoring
  • hyperoxia
  • hypoxia

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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