Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask, Mary K. Vaughan, Russel J Reiter

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Abstract

Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

Original languageEnglish (US)
Pages (from-to)91-93
Number of pages3
JournalNeuroscience Letters
Volume6
Issue number2-3
DOIs
StatePublished - 1977

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Vasotocin
Adrenergic Antagonists
Prolactin
Haloperidol
Propranolol
In Vitro Techniques

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro. / Blask, David E.; Vaughan, Mary K.; Reiter, Russel J.

In: Neuroscience Letters, Vol. 6, No. 2-3, 1977, p. 91-93.

Research output: Contribution to journalArticle

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