Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask; Mary K. Vaughan; Russel J. Reiter

doi:10.1016/0304-3940(77)90001-5

Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask, Mary K. Vaughan, Russel J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10^-9 haloperidol, 4·10^-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

Original language	English (US)
Pages (from-to)	91-93
Number of pages	3
Journal	Neuroscience Letters
Volume	6
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(77)90001-5
State	Published - Nov 1977

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(77)90001-5

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@article{cd250e9787b64cc1b531d7a05e14b177,

title = "Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro",

abstract = "Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.",

author = "Blask, {David E.} and Vaughan, {Mary K.} and Reiter, {Russel J.}",

note = "Funding Information: The authors wish to thank the National Institute of Arthritis, Metabolism and Digestive Diseases {"}Rat Pituitary Hormone Distribution Program for supplying the reagents forthe radioimmunoassay. This work was supported by NSF Grant PCM-74-06276-A02.",

year = "1977",

month = nov,

doi = "10.1016/0304-3940(77)90001-5",

language = "English (US)",

volume = "6",

pages = "91--93",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

AU - Blask, David E.

AU - Vaughan, Mary K.

AU - Reiter, Russel J.

N1 - Funding Information: The authors wish to thank the National Institute of Arthritis, Metabolism and Digestive Diseases "Rat Pituitary Hormone Distribution Program for supplying the reagents forthe radioimmunoassay. This work was supported by NSF Grant PCM-74-06276-A02.

PY - 1977/11

Y1 - 1977/11

N2 - Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

AB - Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

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U2 - 10.1016/0304-3940(77)90001-5

DO - 10.1016/0304-3940(77)90001-5

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JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2-3

ER -

Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

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