Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask; Mary K. Vaughan; Russel J. Reiter

doi:10.1016/0304-3940(77)90001-5

Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask, Mary K. Vaughan, Russel J. Reiter

Cell Systems & Anatomy

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Abstract

Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10^-9 haloperidol, 4·10^-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

Original language	English (US)
Pages (from-to)	91-93
Number of pages	3
Journal	Neuroscience Letters
Volume	6
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(77)90001-5
State	Published - Nov 1977

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ASJC Scopus subject areas

Neuroscience(all)

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Blask, D. E., Vaughan, M. K., & Reiter, R. J. (1977). Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro. Neuroscience Letters, 6(2-3), 91-93. https://doi.org/10.1016/0304-3940(77)90001-5

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N2 - Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

AB - Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

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10.1016/0304-3940(77)90001-5