Modification by adrenergic blocking agents of arginine vasotocin-induced prolactin secretion in vitro

David E. Blask, Mary K. Vaughan, Russel J. Reiter

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Normal male rat hemipituitaries incubated in the presence of 1 μg of arginine vasotocin (AVT) released significantly more prolactin into the incubation medium than their corresponding untreated control halves. Prolactin secretion from hemipituitaries incubated in the presence of 5·10-9 haloperidol, 4·10-5 M propranolol or haloperidol plus AVT was unaffected by these treatments. However, the release of prolactin from hemipituitaries incubated with propranolol plus AVT was significantly inhibited (by 40%) compared with the control glands treated with AVT alone.

Original languageEnglish (US)
Pages (from-to)91-93
Number of pages3
JournalNeuroscience Letters
Issue number2-3
StatePublished - Nov 1977


ASJC Scopus subject areas

  • Neuroscience(all)

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