TY - JOUR
T1 - Modifiable lifestyle and medical risk factors associated with myeloproliferative neoplasms
AU - Duncombe, Andrew S.
AU - Anderson, Lesley A.
AU - James, Glen
AU - De Vocht, Frank
AU - Fritschi, Lin
AU - Mesa, Ruben
AU - Clarke, Mike
AU - McMullin, Mary Frances
N1 - Funding Information:
Ethical approval was obtained from the Office for Research Ethics Committee, Northern Ireland (ORECNI 12/NI/0165). All participants provided written informed consent. The study was performed in accordance with the Declaration of Helsinki. This work was supported by MPN Voice (grant number 0001); GJ was a PhD candidate at Queen’s University Belfast supported by funding from MPN Voice; LF is supported by fellowships from the National Health and Medical Research Council and Cancer Council Western Australia. The authors have no conflicts of interest to disclose. 1Department of Hematology, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom. 2Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland. 3School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom 4School of Public Health, Curtin University, Perth, Western Australia. 5Mayo Clinic Cancer Center, Scottsdale/Phoenix, AR. 6Centre for Medical Education, Queen’s University Belfast, Belfast, Northern Ireland and Belfast Health and Social Care Trust, Northern Ireland. Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. HemaSphere (2020) 4:1(e327) Received: 29 September 2019 / Received in final form: 17 November 2019 / Accepted: 19 November 2019 Citation: Duncombe AS, Anderson LA, James G, de Vocht F, Fritschi L, Mesa R, Clarke M, McMullin MF. Modifiable lifestyle and medical risk factors associated with myeloproliferative neoplasms. HemaSphere, 2020;4:1. http:// dx.doi.org/10.1097/HS9.0000000000000327
Funding Information:
We thank all the participants who contributed to the study. The work was supported by Queen’s University Belfast’s Centre for Public Health. The MOSAICC Study team acknowledges the support of the National Institute for Health Research, through the Northern Ireland Cancer Research Network (NICRN) and for Southampton, the Wessex Cancer Research Network. The MOSAICC Study team also acknowledges the support of research nurses Emma Gaunt of Southampton and Claire Leathem of Belfast. The interpretation and reporting of these data are the sole responsibility of the authors.
Publisher Copyright:
© 2020 Wolters Kluwer Health. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Despite the identification of acquired genetic mutations associated with Myeloproliferative Neoplasms (MPNs) there is a paucity of information relating to modifiable risk factors that may lead to these mutations. The MOSAICC Study was an exploratory case-control study of polycythemia vera (PV), essential thrombocythemia (ET), and Myelofibrosis (MF). MPN patients and population controls (identified by General Practitioners) and non-blood relative/friend controls were recruited from 2 large UK centers. Participants completed a telephone-based questionnaire analyzed by unconditional logistic regression analysis adjusting for potential confounders. Risk factors for MPNs identified included increasing childhood household density [odds ratio (OR) 2.55, 95% confidence interval (CI) 1.16-5.62], low childhood socioeconomic status (OR 2.30, 95%CI 1.02-5.18) and high pack years smoking (OR 2.19, 95%CI 1.03-4.66) and current smoking restricted to JAK2 positive PV cases (OR 3.73, 95%CI 1.06-13.15). Obesity was linked with ET (OR 2.59, 95%CI 1.02-6.58) confirming results in previous cohort studies. Receipt of multiple CT scans was associated with a strongly increased risk of MPN although with wide confidence intervals (OR 5.38, 95%CI 1.67-17.3). Alcohol intake was inversely associated with risk of PV (OR 0.41, 95%CI 0.19-0.92) and ET (OR 0.48, 95%CI 0.24-0.98). The associations with childhood household density, high pack years smoking and alcohol were also seen in multivariate analysis. This is the largest case control study in MPNs to date and confirms the previously reported associations with obesity and cigarette smoking from cohort studies in addition to novel associations. In particular, the role of smoking and JAK2 mutation cases merits further evaluation.
AB - Despite the identification of acquired genetic mutations associated with Myeloproliferative Neoplasms (MPNs) there is a paucity of information relating to modifiable risk factors that may lead to these mutations. The MOSAICC Study was an exploratory case-control study of polycythemia vera (PV), essential thrombocythemia (ET), and Myelofibrosis (MF). MPN patients and population controls (identified by General Practitioners) and non-blood relative/friend controls were recruited from 2 large UK centers. Participants completed a telephone-based questionnaire analyzed by unconditional logistic regression analysis adjusting for potential confounders. Risk factors for MPNs identified included increasing childhood household density [odds ratio (OR) 2.55, 95% confidence interval (CI) 1.16-5.62], low childhood socioeconomic status (OR 2.30, 95%CI 1.02-5.18) and high pack years smoking (OR 2.19, 95%CI 1.03-4.66) and current smoking restricted to JAK2 positive PV cases (OR 3.73, 95%CI 1.06-13.15). Obesity was linked with ET (OR 2.59, 95%CI 1.02-6.58) confirming results in previous cohort studies. Receipt of multiple CT scans was associated with a strongly increased risk of MPN although with wide confidence intervals (OR 5.38, 95%CI 1.67-17.3). Alcohol intake was inversely associated with risk of PV (OR 0.41, 95%CI 0.19-0.92) and ET (OR 0.48, 95%CI 0.24-0.98). The associations with childhood household density, high pack years smoking and alcohol were also seen in multivariate analysis. This is the largest case control study in MPNs to date and confirms the previously reported associations with obesity and cigarette smoking from cohort studies in addition to novel associations. In particular, the role of smoking and JAK2 mutation cases merits further evaluation.
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U2 - 10.1097/HS9.0000000000000327
DO - 10.1097/HS9.0000000000000327
M3 - Article
AN - SCOPUS:85088576710
VL - 4
JO - HemaSphere
JF - HemaSphere
SN - 2572-9241
IS - 1
M1 - e327
ER -