Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults

Camille R. Brightwell, Melissa M. Markofski, Tatiana Moro, Christopher S. Fry, Craig Porter, Elena Volpi, Blake B. Rasmussen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Sarcopenia, age-associated involuntary loss of muscle and strength, can progress to clinically relevant functional decline. Resistance exercise attenuates muscle and strength loss but may not be feasible for some older adults. Aerobic exercise training (AET) improves cardiopulmonary health; however, effects on protein turnover, muscle mass, and strength are less clear. We aimed to determine whether AET improves basal myofibrillar protein synthesis (MPS) and capillarization, promoting hypertrophy and strength. We hypothesized that AET improves strength with increased MPS and capillarization. Older adults were randomized to non-exercise (NON; n = 11, 71.4 ± 4.18 years) or exercise (EX; n = 12, 73.7 ± 4.05 years). EX completed 24 weeks of AET (walking 3×/week, 45 minutes, 70% heart rate reserve); NON remained sedentary. A stable isotope tracer was infused. MPS and capillarization were analyzed from vastus lateralis muscle biopsies. Strength was measured via isokinetic dynamometry. Lean mass was determined with dual-energy X-ray absorptiometry. Basal MPS increased in EX (+50.7%, P = 0.01) along with capillary density (+66.4%, P = 0.03), peak oxygen consumption (+15.8%, P = 0.01), quadriceps strength (+15.1%, P = 0.01), and muscle quality (peak torque divided by leg lean mass, +15.5%, P = 0.01). Lean mass did not change (P > 0.05). AET increases muscle protein turnover and capillarization in older adults, improving muscle quality.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalTranslational Sports Medicine
Issue number3
StatePublished - Apr 2019
Externally publishedYes


  • capillarization
  • protein turnover
  • sarcopenia
  • strength
  • walking exercise

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


Dive into the research topics of 'Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults'. Together they form a unique fingerprint.

Cite this