Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on α1- and α2-adrenergic receptors in the fetal baboon liver

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Abstract

Hepatic α-adrenergic receptors (α-ARs) play a pivotal role in mobilization of reserves via gluconeogenesis and glycogenolysis to supply the animal with its energy needs during decreased nutrient availability. Using a unique nutrient-deprived baboon model, we have demonstrated for the first time that immunoreactive hepatic α1- and α2-AR subtypes are regionally distributed and localized on cells around the central lobular vein in 0.5 and 0.9 gestation (G) fetuses of ad libitum fed control (CTR) and maternal nutrient restricted (MNR) mothers. Furthermore, MNR decreased fetal liver immunoreactive α1-AR and increased immunoreactive α2-AR at 0.5G. However, at 0.9G, immunohistochemistry and Western blot analysis revealed a decrease in α1-AR and no change in α2-AR levels. Thus, MNR in a nonhuman primate species has effects on hepatic α1- and α2-ARs that are receptor- and gestation stage-specific and may represent compensatory systems whose effects would increase glucose availability in the presence of nutrient deprivation.

Original languageEnglish (US)
Pages (from-to)398-405
Number of pages8
JournalReproductive Sciences
Volume18
Issue number4
DOIs
StatePublished - Apr 1 2011

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Keywords

  • baboon
  • gene expression
  • immunolocalization
  • protein expression
  • α-adrenergic receptor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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