TY - CHAP
T1 - Models of Sarcopenia
AU - Fisher, Alfred L.
N1 - Funding Information:
The author has no financial conflicts of interest to report. This work was supported by NIH grant NIH K08 Award 1K08AG024414.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - This chapter offers an introduction to sarcopenia and the current methods used to investigate sarcopenia both in people and experimental systems. Sarcopenia refers to the loss of muscle mass during normal aging. The medical importance of sarcopenia lies in the significant loss of muscle strength that accompanies the loss of muscle mass. The cause of sarcopenia is unknown, but there is evidence from human and experimental animals for multiple theories, including loss of motor neurons, oxidative stress, decline in catabolic hormones, increase in inflammatory cytokines, and inadequate nutrition. Changes in muscle protein synthesis and turnover could account for at least part of the loss of muscle mass and strength during aging. Although studies have suggested that there are no changes in overall muscle synthesis, there seem to be selective changes in specific muscle proteins. Vertebrate muscles contain satellite cells that are quiescent myoblasts that have the ability to proliferate, differentiate, and fuse together to form new muscle fibers.
AB - This chapter offers an introduction to sarcopenia and the current methods used to investigate sarcopenia both in people and experimental systems. Sarcopenia refers to the loss of muscle mass during normal aging. The medical importance of sarcopenia lies in the significant loss of muscle strength that accompanies the loss of muscle mass. The cause of sarcopenia is unknown, but there is evidence from human and experimental animals for multiple theories, including loss of motor neurons, oxidative stress, decline in catabolic hormones, increase in inflammatory cytokines, and inadequate nutrition. Changes in muscle protein synthesis and turnover could account for at least part of the loss of muscle mass and strength during aging. Although studies have suggested that there are no changes in overall muscle synthesis, there seem to be selective changes in specific muscle proteins. Vertebrate muscles contain satellite cells that are quiescent myoblasts that have the ability to proliferate, differentiate, and fuse together to form new muscle fibers.
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U2 - 10.1016/B978-012369391-4/50082-5
DO - 10.1016/B978-012369391-4/50082-5
M3 - Chapter
AN - SCOPUS:84882904206
SN - 9780123693914
SP - 977
EP - 991
BT - Handbook of Models for Human Aging
PB - Elsevier Inc.
ER -