Models of pneumococcal disease

Carlos J. Orihuela, Elaine I. Tuomanen

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Streptococcus pneumoniae is a leading cause of invasive Gram-positive disease. Infection progresses from the nasopharynx to otitis, pneumonia, bacteremia, sepsis and meningitis. Steadily increasing multidrug resistance has forced testing of new antibiotics and vaccines, as well as new adjunctive therapies based on insights into pathogenesis. This review discusses the models for each disease manifestation from both the host and bacterial perspectives and their impact on discovery of new therapeutics.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number1
StatePublished - Apr 27 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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