Models of pneumococcal disease

Carlos J. Orihuela; Elaine I. Tuomanen

doi:10.1016/j.ddmod.2006.03.001

Models of pneumococcal disease

Carlos J. Orihuela, Elaine I. Tuomanen

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Streptococcus pneumoniae is a leading cause of invasive Gram-positive disease. Infection progresses from the nasopharynx to otitis, pneumonia, bacteremia, sepsis and meningitis. Steadily increasing multidrug resistance has forced testing of new antibiotics and vaccines, as well as new adjunctive therapies based on insights into pathogenesis. This review discusses the models for each disease manifestation from both the host and bacterial perspectives and their impact on discovery of new therapeutics.

Original language	English (US)
Pages (from-to)	69-75
Number of pages	7
Journal	Drug Discovery Today: Disease Models
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmod.2006.03.001
State	Published - Apr 27 2006

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2006.03.001

Cite this

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abstract = "Streptococcus pneumoniae is a leading cause of invasive Gram-positive disease. Infection progresses from the nasopharynx to otitis, pneumonia, bacteremia, sepsis and meningitis. Steadily increasing multidrug resistance has forced testing of new antibiotics and vaccines, as well as new adjunctive therapies based on insights into pathogenesis. This review discusses the models for each disease manifestation from both the host and bacterial perspectives and their impact on discovery of new therapeutics.",

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AB - Streptococcus pneumoniae is a leading cause of invasive Gram-positive disease. Infection progresses from the nasopharynx to otitis, pneumonia, bacteremia, sepsis and meningitis. Steadily increasing multidrug resistance has forced testing of new antibiotics and vaccines, as well as new adjunctive therapies based on insights into pathogenesis. This review discusses the models for each disease manifestation from both the host and bacterial perspectives and their impact on discovery of new therapeutics.

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Models of pneumococcal disease

Abstract

ASJC Scopus subject areas

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