TY - CHAP
T1 - Models of Hypertension in Aging
AU - Reckelhoff, Jane F.
AU - Iliescu, Radu
AU - Yanes, Licy
AU - Fortepiani, Lourdes A.
N1 - Funding Information:
The authors wish to acknowledge the support of the National Institutes of Health HL66072, HL69194, and HL05197.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - There are both genetic and nongenetic models of hypertension in which the animals exhibit increases in blood pressure spontaneously or are genetically predisposed to increase blood pressure in response to a high-salt diet. Providing the strongest support for the theory that renal dysfunction in the excretion of sodium and water is the etiology of hypertension are observations that "hypertension follows the kidney." Men are generally at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Various humoral and cardiovascular systems play a role in controlling blood pressure. Among them are the rennin-angiotensin-aldosterone system, endothelin, oxidative stress, obesity, and the sympathetic nervous system. The key system for controlling blood pressure and body fluid volume is the rennin-angiotensin-aldosterone system (RAAS.) Superoxide is known to interact with nitric oxide (NO) to cause quenching of NO and to produce peroxynitrite, one of the most potent oxidative compounds known. Endothelin is a potent vasoconstrictor that when infused chronically leads to increase in blood pressure.
AB - There are both genetic and nongenetic models of hypertension in which the animals exhibit increases in blood pressure spontaneously or are genetically predisposed to increase blood pressure in response to a high-salt diet. Providing the strongest support for the theory that renal dysfunction in the excretion of sodium and water is the etiology of hypertension are observations that "hypertension follows the kidney." Men are generally at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Various humoral and cardiovascular systems play a role in controlling blood pressure. Among them are the rennin-angiotensin-aldosterone system, endothelin, oxidative stress, obesity, and the sympathetic nervous system. The key system for controlling blood pressure and body fluid volume is the rennin-angiotensin-aldosterone system (RAAS.) Superoxide is known to interact with nitric oxide (NO) to cause quenching of NO and to produce peroxynitrite, one of the most potent oxidative compounds known. Endothelin is a potent vasoconstrictor that when infused chronically leads to increase in blood pressure.
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U2 - 10.1016/B978-012369391-4/50084-9
DO - 10.1016/B978-012369391-4/50084-9
M3 - Chapter
AN - SCOPUS:84882901612
SN - 9780123693914
SP - 999
EP - 1009
BT - Handbook of Models for Human Aging
PB - Elsevier Inc.
ER -