Models of hypertension in aging

Jane F. Reckelhoff; Licy L. Yanes Cardozo; Maria Lourdes Alarcon Fortepiani

doi:10.1016/B978-0-12-811353-0.00052-X

Models of hypertension in aging

Jane F. Reckelhoff, Licy L. Yanes Cardozo, Maria Lourdes Alarcon Fortepiani

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Aging is associated with a high incidence and prevalence of arterial hypertension. While all forms of hypertension studied to date are caused by a defect in the handling of sodium and water by the kidney, genetic, environmental, and neuroendocrine alterations contribute to the development and maintenance of hypertension. Some mechanisms that can play a role in hypertension have been studied extensively, including the renin-angiotensin-aldosterone system, nitric oxide, endothelin, inflammation, oxidative stress, sympathetic nervous system, androgen/estrogen ratio, and obesity. Special interest is focused on the sex difference in blood pressure control in humans and animals, with males having higher blood pressure than females until they reach menopause and may become hypertensive.

Original language	English (US)
Title of host publication	Conn's Handbook of Models for Human Aging
Publisher	Elsevier
Pages	703-720
Number of pages	18
ISBN (Electronic)	9780128113530
DOIs	https://doi.org/10.1016/B978-0-12-811353-0.00052-X
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Aging
Dahl salt-sensitive rats
Endothelin
Gender
Hypertension
Inflammation
Menopause
Oxidative stress
Renal dysfunction
Renin-angiotensin-aldosterone system
Spontaneously hypertensive rats (SHRs)

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-811353-0.00052-X

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Cite this

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abstract = "Aging is associated with a high incidence and prevalence of arterial hypertension. While all forms of hypertension studied to date are caused by a defect in the handling of sodium and water by the kidney, genetic, environmental, and neuroendocrine alterations contribute to the development and maintenance of hypertension. Some mechanisms that can play a role in hypertension have been studied extensively, including the renin-angiotensin-aldosterone system, nitric oxide, endothelin, inflammation, oxidative stress, sympathetic nervous system, androgen/estrogen ratio, and obesity. Special interest is focused on the sex difference in blood pressure control in humans and animals, with males having higher blood pressure than females until they reach menopause and may become hypertensive.",

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KW - Gender

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