Models of hypertension in aging

Jane F. Reckelhoff, Licy L. Yanes Cardozo, Maria Lourdes Alarcon Fortepiani

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Aging is associated with a high incidence and prevalence of arterial hypertension. While all forms of hypertension studied to date are caused by a defect in the handling of sodium and water by the kidney, genetic, environmental, and neuroendocrine alterations contribute to the development and maintenance of hypertension. Some mechanisms that can play a role in hypertension have been studied extensively, including the renin-angiotensin-aldosterone system, nitric oxide, endothelin, inflammation, oxidative stress, sympathetic nervous system, androgen/estrogen ratio, and obesity. Special interest is focused on the sex difference in blood pressure control in humans and animals, with males having higher blood pressure than females until they reach menopause and may become hypertensive.

Original languageEnglish (US)
Title of host publicationConn's Handbook of Models for Human Aging
Number of pages18
ISBN (Electronic)9780128113530
StatePublished - Jan 1 2018
Externally publishedYes


  • Aging
  • Dahl salt-sensitive rats
  • Endothelin
  • Gender
  • Hypertension
  • Inflammation
  • Menopause
  • Oxidative stress
  • Renal dysfunction
  • Renin-angiotensin-aldosterone system
  • Spontaneously hypertensive rats (SHRs)

ASJC Scopus subject areas

  • Medicine(all)


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