Models of dengue virus infection

Dennis A. Bente, Rebeca Rico-Hesse

    Research output: Contribution to journalReview articlepeer-review

    66 Scopus citations

    Abstract

    The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.

    Original languageEnglish (US)
    Pages (from-to)97-103
    Number of pages7
    JournalDrug Discovery Today: Disease Models
    Volume3
    Issue number1
    DOIs
    StatePublished - 2006

    ASJC Scopus subject areas

    • Molecular Medicine
    • Drug Discovery

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