Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study

M. P. Saccomani, C. Cobelli, A. Gabana, E. Ferrannini, R. Bonadonna, R. A. Gelfand, R. A. De Fronzo

Research output: Contribution to journalConference article

Abstract

In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalIFAC Proceedings Series
Issue number1
StatePublished - Dec 1 1989
Externally publishedYes
EventIFAC Symposium on Modelling and Control in Biomedical Systems - Venice, Italy
Duration: Apr 6 1988Apr 8 1988

ASJC Scopus subject areas

  • Engineering(all)

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    Saccomani, M. P., Cobelli, C., Gabana, A., Ferrannini, E., Bonadonna, R., Gelfand, R. A., & De Fronzo, R. A. (1989). Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study. IFAC Proceedings Series, (1), 345-350.