Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study

M. P. Saccomani; C. Cobelli; A. Gabana; E. Ferrannini; R. Bonadonna; R. A. Gelfand; R. A. De Fronzo

Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study

M. P. Saccomani, C. Cobelli, A. Gabana, E. Ferrannini, R. Bonadonna, R. A. Gelfand, R. A. De Fronzo

Research output: Contribution to journal › Conference article › peer-review

Abstract

In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.

Original language	English (US)
Pages (from-to)	345-350
Number of pages	6
Journal	IFAC Proceedings Series
Issue number	1
State	Published - 1989
Externally published	Yes
Event	IFAC Symposium on Modelling and Control in Biomedical Systems - Venice, Italy Duration: Apr 6 1988 → Apr 8 1988

ASJC Scopus subject areas

General Engineering

Cite this

@article{361651e5f1ad4a43b9a4d7c42d3c6031,

title = "Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study",

abstract = "In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.",

author = "Saccomani, {M. P.} and C. Cobelli and A. Gabana and E. Ferrannini and R. Bonadonna and Gelfand, {R. A.} and {De Fronzo}, {R. A.}",

year = "1989",

language = "English (US)",

pages = "345--350",

journal = "IFAC Proceedings Series",

issn = "0741-1146",

publisher = "Pergamon Press Ltd.",

number = "1",

note = "IFAC Symposium on Modelling and Control in Biomedical Systems ; Conference date: 06-04-1988 Through 08-04-1988",

}

TY - JOUR

T1 - Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study

AU - Saccomani, M. P.

AU - Cobelli, C.

AU - Gabana, A.

AU - Ferrannini, E.

AU - Bonadonna, R.

AU - Gelfand, R. A.

AU - De Fronzo, R. A.

PY - 1989

Y1 - 1989

N2 - In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.

AB - In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.

UR - http://www.scopus.com/inward/record.url?scp=0024935454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024935454&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0024935454

SN - 0741-1146

SP - 345

EP - 350

JO - IFAC Proceedings Series

JF - IFAC Proceedings Series

IS - 1

T2 - IFAC Symposium on Modelling and Control in Biomedical Systems

Y2 - 6 April 1988 through 8 April 1988

ER -

Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this