Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme

Yu Chiao Chiu; Eric Y. Chuang; Tzu Hung Hsiao; Yidong Chen

doi:10.1109/BIBM.2013.6732489

Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme

Yu Chiao Chiu, Eric Y. Chuang, Tzu Hung Hsiao, Yidong Chen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Recent studies postulated that genes harboring identical microRNA (miRNA) binding sites can crosstalk by competing for a limited pool of the binding miRNAs (the miRNA program), named as the regulation of competing endogenous RNAs (ceRNAs). Incorporating recent biological evidence that ceRNA regulation depends on miRNA program expression levels, we developed, in the present study, a mathematical model for systematically inferring ceRNA regulation that is dependent on expression levels of the miRNA programs from sample-paired mRNA and miRNA expression datasets. Applying the method to analyze glioblastoma datasets, a compact ceRNA regulatory network was constructed. Our data further demonstrated that ceRNA regulation plays an essential role in transient cellular responses to dynamic inter-cellular signals. The findings illuminate mechanism of ceRNA regulation and further provide biological insights into the complex human interactome.

Original language	English (US)
Title of host publication	Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Pages	201-204
Number of pages	4
DOIs	https://doi.org/10.1109/BIBM.2013.6732489
State	Published - 2013
Event	2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013 - Shanghai, China Duration: Dec 18 2013 → Dec 21 2013

Publication series

Name	Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013

Other

Other	2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Country/Territory	China
City	Shanghai
Period	12/18/13 → 12/21/13

Keywords

competing endogenous RNA
gene regulatory network
glioblastoma multiforme

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1109/BIBM.2013.6732489

Cite this

Chiu, Y. C., Chuang, E. Y., Hsiao, T. H., & Chen, Y. (2013). Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme. In Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013 (pp. 201-204). Article 6732489 (Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013). https://doi.org/10.1109/BIBM.2013.6732489

Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme. / Chiu, Yu Chiao; Chuang, Eric Y.; Hsiao, Tzu Hung et al.
Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013. 2013. p. 201-204 6732489 (Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chiu, YC, Chuang, EY, Hsiao, TH & Chen, Y 2013, Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme. in Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013., 6732489, Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013, pp. 201-204, 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013, Shanghai, China, 12/18/13. https://doi.org/10.1109/BIBM.2013.6732489

Chiu YC, Chuang EY, Hsiao TH, Chen Y. Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme. In Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013. 2013. p. 201-204. 6732489. (Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013). doi: 10.1109/BIBM.2013.6732489

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Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme

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