Model for the neuromuscular complications of systemic lupus erythematosus

R. L. Brey, S. Cote, R. Barohn, C. Jackson, R. Crawley, J. M. Teale

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The purpose of this study is to evaluate nerve and muscle physiology and histopathology in a murine lupus model. Muscle strength, compound muscle action potentials (distal latency and amplitude), proximal limb muscle, sciatic nerve and joint specimens were studied in MRL/lpr (lupus model) and MRL/++ (control) mice. MRL/lpr mice showed decreased muscle strength (P < 10-6, Wilcoxon rank sum), lower compound muscle action potential mean amplitude and prolonged distal latency (P = 0.005 and 0.042, Mann-Whitney U-test), and muscle and nerve inflammation (P = 0.002 and P = 0.037, Fisher's exact test) compared with MRL/++ mice. The MRL/lpr strain evaluated in this study demonstrated muscle weakness, abnormal motor nerve conduction studies and inflammation of both muscle and nerve. These features make it an excellent model for studying the neuromuscular complications of lupus.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalLupus
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1995

Keywords

  • Conduction study
  • Inflammation nerve
  • Murine models
  • Neuromuscular complications

ASJC Scopus subject areas

  • Rheumatology

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