Mitoxantrone hydrochloride (NSC-310739) in lymphoma - A Southwest Oncology Group study

Charles A. Coltman; Terri M. McDaniel; Stanley P. Balcerzak; Francis S. Morrison; Daniel D. Von Hoff

doi:10.1007/BF00180193

Mitoxantrone hydrochloride (NSC-310739) in lymphoma - A Southwest Oncology Group study

Charles A. Coltman, Terri M. McDaniel, Stanley P. Balcerzak, Francis S. Morrison, Daniel D. Von Hoff

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The members of the Southwest Oncology Group have treated thirteen patients with Hodgkin's disease and thirty-seven with non-Hodgkin's lymphoma with mitoxantrone on the every three week schedule. While the result (\313 responses in Hodgkin's; \937 responses in non-Hodgkin's lymphoma) is not striking, there is a definite antitumor activity in a very heavily pretreated group of patients. Toxicity was acceptable. Additional trials in lymphoma are planned using mitoxantrone in combination with BCNU.

Original language	English (US)
Pages (from-to)	65-70
Number of pages	6
Journal	Investigational New Drugs
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/BF00180193
State	Published - Mar 1983
Externally published	Yes

Keywords

Hodgkin's disease
mitoxantrone
non-Hodgkin's lymphoma

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1007/BF00180193

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title = "Mitoxantrone hydrochloride (NSC-310739) in lymphoma - A Southwest Oncology Group study",

abstract = "The members of the Southwest Oncology Group have treated thirteen patients with Hodgkin's disease and thirty-seven with non-Hodgkin's lymphoma with mitoxantrone on the every three week schedule. While the result (\313 responses in Hodgkin's; \937 responses in non-Hodgkin's lymphoma) is not striking, there is a definite antitumor activity in a very heavily pretreated group of patients. Toxicity was acceptable. Additional trials in lymphoma are planned using mitoxantrone in combination with BCNU.",

keywords = "Hodgkin's disease, mitoxantrone, non-Hodgkin's lymphoma",

author = "Coltman, {Charles A.} and McDaniel, {Terri M.} and Balcerzak, {Stanley P.} and Morrison, {Francis S.} and {Von Hoff}, {Daniel D.}",

year = "1983",

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doi = "10.1007/BF00180193",

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T1 - Mitoxantrone hydrochloride (NSC-310739) in lymphoma - A Southwest Oncology Group study

AU - Coltman, Charles A.

AU - McDaniel, Terri M.

AU - Balcerzak, Stanley P.

AU - Morrison, Francis S.

AU - Von Hoff, Daniel D.

PY - 1983/3

Y1 - 1983/3

N2 - The members of the Southwest Oncology Group have treated thirteen patients with Hodgkin's disease and thirty-seven with non-Hodgkin's lymphoma with mitoxantrone on the every three week schedule. While the result (\313 responses in Hodgkin's; \937 responses in non-Hodgkin's lymphoma) is not striking, there is a definite antitumor activity in a very heavily pretreated group of patients. Toxicity was acceptable. Additional trials in lymphoma are planned using mitoxantrone in combination with BCNU.

AB - The members of the Southwest Oncology Group have treated thirteen patients with Hodgkin's disease and thirty-seven with non-Hodgkin's lymphoma with mitoxantrone on the every three week schedule. While the result (\313 responses in Hodgkin's; \937 responses in non-Hodgkin's lymphoma) is not striking, there is a definite antitumor activity in a very heavily pretreated group of patients. Toxicity was acceptable. Additional trials in lymphoma are planned using mitoxantrone in combination with BCNU.

KW - Hodgkin's disease

KW - mitoxantrone

KW - non-Hodgkin's lymphoma

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Mitoxantrone hydrochloride (NSC-310739) in lymphoma - A Southwest Oncology Group study

Abstract

Keywords

ASJC Scopus subject areas

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