Mitomycin-c application in airway stenosis surgery: Analysis of safety and costs

Matthew L. Ubell, Sandra L. Ettema, Robert J. Toohill, C. Blake Simpson, Albert L. Merati

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


OBJECTIVE: This study describes a large series of patients receiving topical mitomycin-c (MMC) during airway surgery, including complications, and carries out a cost analysis for its use in laryngotracheal stenosis. STUDY DESIGN AND SETTING: Retrospective review, tertiary center. Airway patients receiving MMC are reviewed for demographics, stenosis characteristics, and MMC usage. A basic cost analysis is carried out. RESULTS: Fifty patients underwent 93 MMC applications (mean = 50.8 years, 25 male, 25 female). In 89 of 93 applications (96%), the concentration of MMC was 0.4 mg/ml. One major complication occurred (1.1%). The expense for MMC is $455; the mean cost for airway surgery is $7,840. It is estimated that if 1 of 17 MMC treated patients requires one less operation, the cost ratio is favorable. CONCLUSIONS: This large series contributes to literature that MMC is a safe adjunct to laryngotracheal surgery. The marginal cost for MMC application is favorable based on our basic cost analysis and existing efficacy data. SIGNIFICANCE: Mitomycin-c seems to be safe and cost-effective in endoscopic airway surgery. EBM rating: C-4

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Issue number3
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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