Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype

Hong Seok Kim, Reto Asmis

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalFree Radical Biology and Medicine
Volume109
DOIs
StatePublished - Aug 2017

Keywords

  • Atherosclerosis
  • DUSP
  • MAPK
  • Macrophage
  • Monocyte
  • Redox signaling

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype'. Together they form a unique fingerprint.

Cite this