Abstract
MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.
Original language | English (US) |
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Pages (from-to) | 75-83 |
Number of pages | 9 |
Journal | Free Radical Biology and Medicine |
Volume | 109 |
DOIs | |
State | Published - Aug 2017 |
Keywords
- Atherosclerosis
- DUSP
- MAPK
- Macrophage
- Monocyte
- Redox signaling
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)