Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype

Hong Seok Kim; Reto Asmis

doi:10.1016/j.freeradbiomed.2017.03.020

Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype

Hong Seok Kim, Reto Asmis

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

Original language	English (US)
Pages (from-to)	75-83
Number of pages	9
Journal	Free Radical Biology and Medicine
Volume	109
DOIs	https://doi.org/10.1016/j.freeradbiomed.2017.03.020
State	Published - Aug 2017

Keywords

Atherosclerosis
DUSP
MAPK
Macrophage
Monocyte
Redox signaling

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

Access to Document

10.1016/j.freeradbiomed.2017.03.020

Fingerprint Dive into the research topics of 'Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype'. Together they form a unique fingerprint.

Cite this

@article{b647d9b4d0924269a753fd3ac010321a,

title = "Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype",

abstract = "MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.",

keywords = "Atherosclerosis, DUSP, MAPK, Macrophage, Monocyte, Redox signaling",

author = "Kim, {Hong Seok} and Reto Asmis",

note = "Funding Information: Reto Asmis is supported by grants form the National Institutes of Health (RO1 AT006885 and RO1 HL115858). Hong Seok Kim is supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A5A2009392 and NRF-2016K2A9A1A01947271).",

year = "2017",

month = aug,

doi = "10.1016/j.freeradbiomed.2017.03.020",

language = "English (US)",

volume = "109",

pages = "75--83",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype

AU - Kim, Hong Seok

AU - Asmis, Reto

N1 - Funding Information: Reto Asmis is supported by grants form the National Institutes of Health (RO1 AT006885 and RO1 HL115858). Hong Seok Kim is supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A5A2009392 and NRF-2016K2A9A1A01947271).

PY - 2017/8

Y1 - 2017/8

N2 - MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

AB - MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

KW - Atherosclerosis

KW - DUSP

KW - MAPK

KW - Macrophage

KW - Monocyte

KW - Redox signaling

UR - http://www.scopus.com/inward/record.url?scp=85015955287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015955287&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2017.03.020

DO - 10.1016/j.freeradbiomed.2017.03.020

M3 - Review article

C2 - 28330703

AN - SCOPUS:85015955287

VL - 109

SP - 75

EP - 83

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

ER -