Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype

Hong Seok Kim, Reto Asmis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

Original languageEnglish (US)
JournalFree Radical Biology and Medicine
DOIs
StateAccepted/In press - Jan 13 2017

Keywords

  • Atherosclerosis
  • DUSP
  • Macrophage
  • MAPK
  • Monocyte
  • Redox signaling

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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