Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

Fang Hu, Feng Liu

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

Under pathophysiological conditions such as obesity, excessive oxidation of nutrients may induce mitochondrial stress, leading to mitochondrial unfolded protein response (UPR mt) and initiation of a retrograde stress signaling pathway. Defects in the UPR mt and the retrograde signaling pathways may disrupt the integrity and homeostasis of the mitochondria, resulting in endoplasmic reticulum stress and insulin resistance. Improving the capacity of mitochondria to reduce stress may be an effective approach to improve mitochondria function and to suppress obesity-induced metabolic disorders such as insulin resistance and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1528-1533
Number of pages6
JournalCellular Signalling
Volume23
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Diabetes
  • ER stress
  • Insulin resistance
  • Mitochondria
  • Unfolded protein response

ASJC Scopus subject areas

  • Cell Biology

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