Mitochondrial respiratory complex I: Structure, function and implication in human diseases

Lokendra K. Sharma, Jianxin Lu, Yidong Bai

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.

Original languageEnglish (US)
Pages (from-to)1266-1277
Number of pages12
JournalCurrent Medicinal Chemistry
Volume16
Issue number10
DOIs
StatePublished - 2009

Keywords

  • Apoptosis
  • Complex I
  • Complex I functions
  • Mitochondria
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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