Abstract
The role of mitochondria in diabetic complications has been viewed as a source of excess superoxide production leading to cell dysfunction. However, with the lack of benefit of non-specific anti-oxidant approaches this view needs to be re-evaluated. With recent studies using real-time imaging of superoxide, metabolomics, flux studies, transcriptomics and proteomics a new appreciation for the role of mitochondria in the evolution of diabetic kidney disease has emerged. Ongoing studies to further unravel the time course and mechanisms that reduce mitochondrial function will be relevant to novel therapies that could have a major impact on diabetic kidney disease and other diabetic complications.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 553-562 |
| Number of pages | 10 |
| DOIs | |
| State | Published - May 1 2017 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 982 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Mitochondrial dysfunction in the diabetic kidney. / Sharma, Kumar.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 553-562 (Advances in Experimental Medicine and Biology; Vol. 982).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mitochondrial dysfunction in the diabetic kidney
AU - Sharma, Kumar
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The role of mitochondria in diabetic complications has been viewed as a source of excess superoxide production leading to cell dysfunction. However, with the lack of benefit of non-specific anti-oxidant approaches this view needs to be re-evaluated. With recent studies using real-time imaging of superoxide, metabolomics, flux studies, transcriptomics and proteomics a new appreciation for the role of mitochondria in the evolution of diabetic kidney disease has emerged. Ongoing studies to further unravel the time course and mechanisms that reduce mitochondrial function will be relevant to novel therapies that could have a major impact on diabetic kidney disease and other diabetic complications.
AB - The role of mitochondria in diabetic complications has been viewed as a source of excess superoxide production leading to cell dysfunction. However, with the lack of benefit of non-specific anti-oxidant approaches this view needs to be re-evaluated. With recent studies using real-time imaging of superoxide, metabolomics, flux studies, transcriptomics and proteomics a new appreciation for the role of mitochondria in the evolution of diabetic kidney disease has emerged. Ongoing studies to further unravel the time course and mechanisms that reduce mitochondrial function will be relevant to novel therapies that could have a major impact on diabetic kidney disease and other diabetic complications.
UR - http://www.scopus.com/inward/record.url?scp=85019974253&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019974253&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-55330-6_28
DO - 10.1007/978-3-319-55330-6_28
M3 - Chapter
T3 - Advances in Experimental Medicine and Biology
SP - 553
EP - 562
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -