Mitochondrial dysfunction in the diabetic kidney

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The role of mitochondria in diabetic complications has been viewed as a source of excess superoxide production leading to cell dysfunction. However, with the lack of benefit of non-specific anti-oxidant approaches this view needs to be re-evaluated. With recent studies using real-time imaging of superoxide, metabolomics, flux studies, transcriptomics and proteomics a new appreciation for the role of mitochondria in the evolution of diabetic kidney disease has emerged. Ongoing studies to further unravel the time course and mechanisms that reduce mitochondrial function will be relevant to novel therapies that could have a major impact on diabetic kidney disease and other diabetic complications.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages553-562
Number of pages10
DOIs
StatePublished - May 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume982
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Mitochondria
Diabetic Nephropathies
Diabetes Complications
Superoxides
Kidney
Metabolomics
Oxidants
Proteomics
Fluxes
Imaging techniques
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sharma, K. (2017). Mitochondrial dysfunction in the diabetic kidney. In Advances in Experimental Medicine and Biology (pp. 553-562). (Advances in Experimental Medicine and Biology; Vol. 982). Springer New York LLC. https://doi.org/10.1007/978-3-319-55330-6_28

Mitochondrial dysfunction in the diabetic kidney. / Sharma, Kumar.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 553-562 (Advances in Experimental Medicine and Biology; Vol. 982).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sharma, K 2017, Mitochondrial dysfunction in the diabetic kidney. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 982, Springer New York LLC, pp. 553-562. https://doi.org/10.1007/978-3-319-55330-6_28
Sharma K. Mitochondrial dysfunction in the diabetic kidney. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2017. p. 553-562. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-55330-6_28
Sharma, Kumar. / Mitochondrial dysfunction in the diabetic kidney. Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. pp. 553-562 (Advances in Experimental Medicine and Biology).
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