Mitochondrial chaperones in human health and disease

Tyler Bahr, Joshua Katuri, Ting Liang, Yidong Bai

Research output: Contribution to journalReview articlepeer-review

Abstract

Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.

Original languageEnglish (US)
Pages (from-to)363-374
Number of pages12
JournalFree Radical Biology and Medicine
Volume179
DOIs
StateAccepted/In press - 2021

Keywords

  • Mitochondrial chaperone
  • Mitochondrial homeostasis
  • Stressresponse
  • mtHsp60
  • mtHsp70

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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