Mitochondrial chaperones in human health and disease

Tyler Bahr; Joshua Katuri; Ting Liang; Yidong Bai

doi:10.1016/j.freeradbiomed.2021.11.015

Mitochondrial chaperones in human health and disease

Tyler Bahr, Joshua Katuri, Ting Liang, Yidong Bai

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.

Original language	English (US)
Pages (from-to)	363-374
Number of pages	12
Journal	Free Radical Biology and Medicine
Volume	179
DOIs	https://doi.org/10.1016/j.freeradbiomed.2021.11.015
State	Published - Feb 1 2022

Keywords

Mitochondrial chaperone
Mitochondrial homeostasis
Stressresponse
mtHsp60
mtHsp70

ASJC Scopus subject areas

Physiology (medical)
Biochemistry

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10.1016/j.freeradbiomed.2021.11.015

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title = "Mitochondrial chaperones in human health and disease",

abstract = "Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.",

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AU - Bahr, Tyler

AU - Katuri, Joshua

AU - Liang, Ting

AU - Bai, Yidong

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.

AB - Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.

KW - Mitochondrial chaperone

KW - Mitochondrial homeostasis

KW - Stressresponse

KW - mtHsp60

KW - mtHsp70

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Mitochondrial chaperones in human health and disease

Abstract

Keywords

ASJC Scopus subject areas

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