Mistaken identity: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus

S. Arunmozhi Balajee, Jennifer Gribskov, Mary Brandt, James Ito, Annette Fothergill, Kieren A. Marr

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Invasive fungal infections caused by Neosartorya pseudofischeri S. W. Peterson [anamorph Aspergillus thermomutatus (Paden) S. W. Peterson] are extremely rare. Phenotypically, the anamorphic state of N. pseudofischeri resembles Aspergillus fumigatus, the predominant agent of invasive aspergillosis in immunocompromised hosts. We report the recovery of three clinical isolates of N. pseudofischeri, all initially misidentified by morphological characteristics as A. fumigatus. All three isolates were correctly identified by sequencing portions of the β-tubulin and the rodlet A genes. Only one of the three isolates produced the confirmatory fruiting bodies and was thus classified as N. pseudofischeri; the other isolates did not produce asci and were therefore identified as A. thermomutatus. All three isolates had higher MICs to voriconazole in vitro compared to A. fumigatus Af293. This report emphasizes that phenotypic identification of filamentous fungi may not identify morphologically similar, but genetically distinct, members of the genus Aspergillus section Fumigati. Accurate identification of these organisms may be clinically meaningful, given their potential differences in antifungal susceptibilities.

Original languageEnglish (US)
Pages (from-to)5996-5999
Number of pages4
JournalJournal of Clinical Microbiology
Volume43
Issue number12
DOIs
StatePublished - Dec 2005

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Neosartorya
Aspergillus fumigatus
Aspergillus
vif Genes
Aspergillosis
Immunocompromised Host
Tubulin
Fungi

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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Mistaken identity : Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus. / Balajee, S. Arunmozhi; Gribskov, Jennifer; Brandt, Mary; Ito, James; Fothergill, Annette; Marr, Kieren A.

In: Journal of Clinical Microbiology, Vol. 43, No. 12, 12.2005, p. 5996-5999.

Research output: Contribution to journalArticle

Balajee, S. Arunmozhi ; Gribskov, Jennifer ; Brandt, Mary ; Ito, James ; Fothergill, Annette ; Marr, Kieren A. / Mistaken identity : Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus. In: Journal of Clinical Microbiology. 2005 ; Vol. 43, No. 12. pp. 5996-5999.
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