MiRNAs: Roles and clinical applications in vascular disease

Md Saha Jamaluddin, Sarah M. Weakley, Lidong Zhang, Panagiotis Kougias, Peter H. Lin, Qizhi Yao, Changyi Chen

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

miRNAs are small, endogenously expressed noncoding RNAs that regulate gene expression, mainly at the post-transcriptional level, via degradation or translational inhibition of their target mRNAs. Functionally, an individual miRNA can regulate the expression of multiple target genes. The study of miRNAs is rapidly growing and recent studies have revealed a significant role of miRNAs in vascular biology and disease. Many miRNAs are highly expressed in the vasculature, and their expression is dysregulated in diseased vessels. Several miRNAs have been found to be critical modulators of vascular pathologies, such as atherosclerosis, lipoprotein metabolism, inflammation, arterial remodeling, angiogenesis, smooth muscle cell regeneration, hypertension, apoptosis, neointimal hyperplasia and signal transduction pathways. Thus, miRNAs may serve as novel biomarkers and/or therapeutic targets for vascular disease. This article summarizes the current studies related to the disease correlations and functional roles of miRNAs in the vascular system and discusses the potential applications of miRNAs in vascular disease.

Original languageEnglish (US)
Pages (from-to)79-89
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Keywords

  • atherosclerosis
  • biomarker
  • lipoprotein metabolism
  • MiRNA
  • therapeutic target
  • vascular disease
  • vascular smooth muscle cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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  • Cite this

    Jamaluddin, M. S., Weakley, S. M., Zhang, L., Kougias, P., Lin, P. H., Yao, Q., & Chen, C. (2011). MiRNAs: Roles and clinical applications in vascular disease. Expert Review of Molecular Diagnostics, 11(1), 79-89. https://doi.org/10.1586/erm.10.103