MiR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin

Sujith Rajan, Ganesh Panzade, Ankita Srivastava, Kripa Shankar, Rajesh Pandey, Durgesh Kumar, Sanchita Gupta, Abhishek Gupta, Salil Varshney, Muheeb Beg, Raj Kumar Mishra, Ravi Shankar, Anil Gaikwad

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


miRNA has been known to regulate diverse cellular and molecular functions. In the earlier study, we have reported that adipocytes differentiated from human mesenchymal stem cells (hMSC) on 72-h chronic insulin (CI) treatment exhibit insulin resistance (IR). Present study has further explored above model to investigate the role of early expressedmiRNAs within human adipocytes to modulate differential adipokine expression as observed during IR. Our results highlight that miR-876-3p regulate glucose homeostasis and its dysregulation leads to IR. We found thatmiR-876-3p level is a critical determinant of adiponectin expression by virtue of its target within adiponectin 3'UTR. Regulatory effect ofmiR-876-3p impacts crosstalk between adiponectin and insulin signaling. Rosiglitazone treatment in CI-induced IR adipocytes drastically reducedmiR-876-3p expression and increased adiponectin level. In line with this, lentiviral-mediated inhibition ofmiR-876-3p expression ameliorated CI and high-fat diet (HFD)-induced IR in adipocytes differentiated from hMSC and C57BL/6 mice, respectively. Our findings thus suggest that modulating miR-876-3p expression could provide novel opportunities for therapeutic intervention of obesity-associated metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalJournal of Endocrinology
Issue number1
StatePublished - Oct 1 2018
Externally publishedYes


  • Adipokines
  • Adiponectin
  • Insulin resistance
  • MiRNA
  • Next generation
  • Sequencing

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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