Mimics of cholangiocarcinoma

Spectrum of disease

Christine O. Menias, Venkateswar R. Surabhi, Srinivasa R. Prasad, Hanlin L. Wang, Vamsi R. Narra, Kedar N Chintapalli

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Cholangiocarcinoma is the second most common primary malignant hepatobiliary neoplasm, accounting for approximately 15% of liver cancers. Diagnosis of cholangiocarcinoma is challenging and the prognosis is uniformly poor, with recurrence rates of 60%-90% after surgical resection. A wide spectrum of neoplastic and nonneoplastic conditions of the biliary tract may masquerade as cholangiocarcinoma, adding to the complexity of management in patients suspected to have cholangiocarcinoma. Mimics of cholangiocarcinoma constitute a heterogeneous group of entities that includes primary sclerosing cholangitis, recurrent pyogenic cholangitis, acquired immunodeficiency syndrome cholangiopathy, autoimmune pancreatitis, inflammatory pseudotumor, Mirizzi syndrome, xanthogranulomatous cholangitis, sarcoidosis, chemotherapy-induced sclerosis, hepatocellular carcinoma, metastases, melanoma, lymphoma, leukemia, and carcinoid tumors. These entities demonstrate characteristic histomorphology and variable clinicobiologic behaviors. The imaging findings of these disparate entities are protean and may be indistinguishable from those of cholangiocarcinoma. In most cases, a definitive diagnosis can be established only with histopathologic examination of a biopsy specimen.

Original languageEnglish (US)
Pages (from-to)1115-1129
Number of pages15
JournalRadiographics
Volume28
Issue number4
DOIs
StatePublished - Mar 2008

Fingerprint

Cholangiocarcinoma
Cholangitis
Mirizzi Syndrome
Plasma Cell Granuloma
Sclerosing Cholangitis
Carcinoid Tumor
Biliary Tract
Sclerosis
Liver Neoplasms
Sarcoidosis
Pancreatitis
Hepatocellular Carcinoma
Melanoma
Lymphoma
Leukemia
Acquired Immunodeficiency Syndrome
Neoplasm Metastasis
Biopsy
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Menias, C. O., Surabhi, V. R., Prasad, S. R., Wang, H. L., Narra, V. R., & Chintapalli, K. N. (2008). Mimics of cholangiocarcinoma: Spectrum of disease. Radiographics, 28(4), 1115-1129. https://doi.org/10.1148/rg.284075148

Mimics of cholangiocarcinoma : Spectrum of disease. / Menias, Christine O.; Surabhi, Venkateswar R.; Prasad, Srinivasa R.; Wang, Hanlin L.; Narra, Vamsi R.; Chintapalli, Kedar N.

In: Radiographics, Vol. 28, No. 4, 03.2008, p. 1115-1129.

Research output: Contribution to journalArticle

Menias, CO, Surabhi, VR, Prasad, SR, Wang, HL, Narra, VR & Chintapalli, KN 2008, 'Mimics of cholangiocarcinoma: Spectrum of disease', Radiographics, vol. 28, no. 4, pp. 1115-1129. https://doi.org/10.1148/rg.284075148
Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN. Mimics of cholangiocarcinoma: Spectrum of disease. Radiographics. 2008 Mar;28(4):1115-1129. https://doi.org/10.1148/rg.284075148
Menias, Christine O. ; Surabhi, Venkateswar R. ; Prasad, Srinivasa R. ; Wang, Hanlin L. ; Narra, Vamsi R. ; Chintapalli, Kedar N. / Mimics of cholangiocarcinoma : Spectrum of disease. In: Radiographics. 2008 ; Vol. 28, No. 4. pp. 1115-1129.
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