TY - JOUR
T1 - Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose-Tolerant Participants
AU - Tripathy, Devjit
AU - Merovci, Aurora
AU - Basu, Rita
AU - Abdul-Ghani, Muhammad
AU - Defronzo, Ralph A.
N1 - Funding Information:
Financial Support: This work was supported by National Institutes of Health grants DK-24092-34 (R.A.D.) and DK-29953-36 (R.B.). D.T.’s salary is supported by the South Texas Veterans Health Care System, Audie Murphy Division.
Publisher Copyright:
© 2019 Endocrine Society.
PY - 2019/3/21
Y1 - 2019/3/21
N2 - Chronic hyperglycemia worsens skeletal muscle insulin resistance and b-cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity is not clear. Objective: To examine the effect of sustained physiologic hyperglycemia (similar to that observed in patients with type 2 diabetes) on endogenous (primarily reflecting hepatic) glucose production (EGP) in healthy individuals. Design: Volunteers participated in a three-step hyperinsulinemic (10, 20, 40 mU/m2 per minute) euglycemic clamp before and after a 48-hour glucose infusion to increase plasma glucose concentration by ;40 mg/dL above baseline. EGP was measured with 3-3H-glucose before and after chronic glucose infusion. Participants: Sixteen persons with normal glucose tolerance [eight with and eight without a family history (FH) of diabetes] participated in the study.
AB - Chronic hyperglycemia worsens skeletal muscle insulin resistance and b-cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity is not clear. Objective: To examine the effect of sustained physiologic hyperglycemia (similar to that observed in patients with type 2 diabetes) on endogenous (primarily reflecting hepatic) glucose production (EGP) in healthy individuals. Design: Volunteers participated in a three-step hyperinsulinemic (10, 20, 40 mU/m2 per minute) euglycemic clamp before and after a 48-hour glucose infusion to increase plasma glucose concentration by ;40 mg/dL above baseline. EGP was measured with 3-3H-glucose before and after chronic glucose infusion. Participants: Sixteen persons with normal glucose tolerance [eight with and eight without a family history (FH) of diabetes] participated in the study.
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U2 - 10.1210/jc.2018-02304
DO - 10.1210/jc.2018-02304
M3 - Article
C2 - 30789980
AN - SCOPUS:85067310268
SN - 0021-972X
VL - 104
SP - 2842
EP - 2850
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
M1 - jcem_201802304
ER -