Mild cognitive impairment (part 2): Biological markers for diagnosis and prediction of dementia in Alzheimer's disease

Orestes V. Forlenza, Breno S. Diniz, Antonio L. Teixeira, Florindo Stella, Wagner Gattaz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012, and based on the following terms: mild cognitive impairment, Alzheimer's disease OR dementia, biomarkers. We retrieved 1,130 articles, of which 175 were reviews. Overall, 955 original articles were eligible. Results: The following points were considered relevant for the present review: a) rationale for biomarkers research in AD and mild cognitive impairment (MCI); b) usefulness of distinct biomarkers for the diagnosis and prediction of AD; c) the role of multimodality biomarkers for the diagnosis and prediction of AD; d) the role of biomarkers in clinical trials of patients with AD and MCI; and e) current limitations to the widespread use of biomarkers in research and clinical settings. Conclusion: Different biomarkers are useful for the early diagnosis and prediction of AD in at-risk subjects. Nonetheless, important methodological limitations need to be overcome for widespread use of biomarkers in research and clinical settings.

Original languageEnglish (US)
Pages (from-to)284-294
Number of pages11
JournalRevista Brasileira de Psiquiatria
Volume35
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid-β protein
  • Biomarkers
  • Mild cognitive impairment
  • Neuroimaging
  • Tau protein

ASJC Scopus subject areas

  • Psychiatry and Mental health

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