Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction

Yong Li, Zheng Huang, Jia Xu, Yong Ding, Dian Yong Tang, Jie Lei, Hong Yu Li, Zhong Zhu Chen, Zhi Gang Xu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.

Original languageEnglish (US)
Pages (from-to)663-669
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume16
DOIs
StatePublished - Apr 9 2020
Externally publishedYes

Keywords

  • Dieckmann cyclization
  • Multicomponent reactions
  • Nitrogen heterocycles
  • One-pot reaction
  • Ugi reaction

ASJC Scopus subject areas

  • Organic Chemistry

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