Abstract
A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.
Original language | English (US) |
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Pages (from-to) | 663-669 |
Number of pages | 7 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 16 |
DOIs | |
State | Published - Apr 9 2020 |
Externally published | Yes |
Keywords
- Dieckmann cyclization
- Multicomponent reactions
- Nitrogen heterocycles
- One-pot reaction
- Ugi reaction
ASJC Scopus subject areas
- Organic Chemistry