Microscopic histopathology of chronic refractory lateral epicondylitis

William Regan, Lester E. Wold, Ralph Coonrad, Bernard F. Morrey

Research output: Contribution to journalArticlepeer-review

264 Scopus citations


The histopathologic features from 11 patients who were treated surgically for lateral epicondylitis were graded and compared to similar tissue from 12 cadaveric spec imens. All studies were done by a single pathologist who had no knowledge of the origin of the specimen. The surgical specimens were interpreted as abnormal in all 11 specimens, and all 12 of the control specimens were reported as being without histologic abnormality. Vascular proliferation was present in 10 of 11 and focal hyaline degeneration was recorded in all 11 of the surgical specimens. Neither feature was present in any of the control material (P < 0.001). These data suggest that chronic refractory lateral epicondylitis requiring sur gery is a degenerative rather than inflammatory proc ess. This may account for the lack of response to rest and antiinflammatory medication.

Original languageEnglish (US)
Pages (from-to)746-749
Number of pages4
JournalThe American Journal of Sports Medicine
Issue number6
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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