MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms

Andrew Ring, Ahmed Ismaeel, Marissa Wechsler, Emma Fletcher, Evlampia Papoutsi, Dimitrios Miserlis, Panagiotis Koutakis

Research output: Contribution to journalReview articlepeer-review

Abstract

Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments.

Original languageEnglish (US)
JournalTherapeutic Advances in Cardiovascular Disease
Volume16
DOIs
StatePublished - 2022

Keywords

  • angiogenesis
  • biomarkers
  • critical limb ischemia
  • hypoxia
  • intermittent claudication
  • non-coding RNAs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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