TY - JOUR
T1 - MicroRNAs and lung cancer
T2 - Tumors and 22-mers
AU - Du, Liqin
AU - Pertsemlidis, Alexander
N1 - Funding Information:
Acknowledgments The authors gratefully acknowledge the technical assistance of Paul Card and thank Robert Borkowski for thoughtful insights and discussions and critical reading of the manuscript. This work was supported in part by Public Health Service grant no. P50 CA70907 from the UT Southwestern/MD Anderson Cancer Center Lung Specialized Program of Research Excellence (UTSW/MDACC Lung SPORE) and the National Cancer Institute and grant no. R01 CA129632 from the National Institutes of Health and the National Cancer Institute.
PY - 2010/3
Y1 - 2010/3
N2 - Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.
AB - Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.
KW - Lung cancer
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=77349116360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77349116360&partnerID=8YFLogxK
U2 - 10.1007/s10555-010-9204-9
DO - 10.1007/s10555-010-9204-9
M3 - Review article
C2 - 20130964
AN - SCOPUS:77349116360
VL - 29
SP - 109
EP - 122
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
SN - 0167-7659
IS - 1
ER -