MicroRNA mediated regulation of immunity against gram-negative bacteria

Jonathon Keck; Rishein Gupta; Lane K. Christenson; Bernard P. Arulanandam

doi:10.1080/08830185.2017.1347649

MicroRNA mediated regulation of immunity against gram-negative bacteria

Jonathon Keck, Rishein Gupta, Lane K. Christenson, Bernard P. Arulanandam

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

Original language	English (US)
Pages (from-to)	287-299
Number of pages	13
Journal	International Reviews of Immunology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1080/08830185.2017.1347649
State	Published - Sep 3 2017

Keywords

Bacteria
gram negative
host immunity
microRNAs

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1080/08830185.2017.1347649

Cite this

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title = "MicroRNA mediated regulation of immunity against gram-negative bacteria",

abstract = "Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.",

keywords = "Bacteria, gram negative, host immunity, microRNAs",

author = "Jonathon Keck and Rishein Gupta and Christenson, {Lane K.} and Arulanandam, {Bernard P.}",

note = "Funding Information: This work was supported by National Institutes of Health Grant (1RO3AI11771401A1), Army Research Office, Department of Defense Contract No. W911NF-11-1-0136 to BPA and National Institute of Child Health and Human Development Grant (HD061580) to LKC. Publisher Copyright: {\textcopyright} 2017 Taylor & Francis.",

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doi = "10.1080/08830185.2017.1347649",

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AU - Gupta, Rishein

AU - Christenson, Lane K.

AU - Arulanandam, Bernard P.

N1 - Funding Information: This work was supported by National Institutes of Health Grant (1RO3AI11771401A1), Army Research Office, Department of Defense Contract No. W911NF-11-1-0136 to BPA and National Institute of Child Health and Human Development Grant (HD061580) to LKC. Publisher Copyright: © 2017 Taylor & Francis.

PY - 2017/9/3

Y1 - 2017/9/3

N2 - Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

AB - Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

KW - Bacteria

KW - gram negative

KW - host immunity

KW - microRNAs

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SN - 0883-0185

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MicroRNA mediated regulation of immunity against gram-negative bacteria

Abstract

Keywords

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