MicroRNA mediated regulation of immunity against gram-negative bacteria

Jonathon Keck, Rishein Gupta, Lane K. Christenson, Bernard P. Arulanandam

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

Original languageEnglish (US)
Pages (from-to)287-299
Number of pages13
JournalInternational Reviews of Immunology
Volume36
Issue number5
DOIs
StatePublished - Sep 3 2017

Keywords

  • Bacteria
  • gram negative
  • host immunity
  • microRNAs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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