MicroRNA cancer therapeutics and the challenge of drug delivery

Steven J. Greco; Jessian L. Munoz; Pranela Rameshwar

doi:10.1007/978-1-4899-8065-6_18

MicroRNA cancer therapeutics and the challenge of drug delivery

Steven J. Greco, Jessian L. Munoz, Pranela Rameshwar

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

MicroRNAs (miRNAs) have progressed to a separate field in cancer biology. As cancer cells undergo investigations to build a hierarchy, the dissection of miRNA in the developmental process occurs in parallel. There is no doubt that RNA interference (RNAi) will be in the clinic. However, the efficiency of the process remains a challenge. This chapter discusses the potential for RNAi in therapy and summarizes some of the different methods to package RNAi for delivery to the regions of cancer. The ability of mesenchymal stem cells to migrate to the site of tumors has been explored as a method to deliver RNAi. However, these stem cells can influence tumor growth and the immune response to tumors. This chapter briefly discusses the potential of using mesenchymal stem cells in RNAi delivery. This topic would require a separate chapter on stem cells and RNAi delivery. Confounds discussed in this chapter are applicable to any method developed with stem cells to target cancer cells with RNAi.

Original language	English (US)
Title of host publication	MicroRNA in Development and in the Progression of Cancer
Publisher	Springer New York
Pages	349-358
Number of pages	10
ISBN (Electronic)	9781489980656
ISBN (Print)	1489980644, 9781489980649
DOIs	https://doi.org/10.1007/978-1-4899-8065-6_18
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Cancer
Drug delivery
MicroRNA
RNAi
Stem cells

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-1-4899-8065-6_18

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