Micropuncture and microperfusion study of glucose excretion in rat parotid saliva

J. A. Mangos, N. Maragos, N. R. McSherry

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The handling of glucose and glucose 14C was studied in the rat parotid using micropuncture and microperfusion techniques. Glucose and glucose 14C concentrations were measured directly in the plasma and final saliva, and glucose 14C was measured in the fluid obtained from the intercalated ducts. In addition, the glucose 14C and 3 O 14C methyl D glucose content of the intracellular water of the gland was calculated and the main duct of the parotid was perfused with saliva containing glucose 14C and inulin 3H. The results of this study show that permeability or transport barriers for glucose exist on both the contraluminal and luminal sides of the secretory cells of the rat parotid; the primary secretory fluid contains glucose in concentrations ranging from 20 to 5% of the concentrations in the intracellular water or plasma water; the excretory ducts of the gland which are impermeable to water are also impermeable to glucose.

Original languageEnglish (US)
Pages (from-to)1260-1264
Number of pages5
JournalAmerican Journal of Physiology
Volume224
Issue number6
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Physiology (medical)

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    Mangos, J. A., Maragos, N., & McSherry, N. R. (1973). Micropuncture and microperfusion study of glucose excretion in rat parotid saliva. American Journal of Physiology, 224(6), 1260-1264.