Micropapillary carcinoma of the urinary bladder: Report of a case and review of its cytologic features

Marlo M. Nicolas, Jaishree S. Jagirdar, Amy M. Arisco, Philip T Valente

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Micropapillary carcinoma (MPC) is an aggressive variant of urothelial carcinoma. MPC has a propensity to invade lymphovascular spaces and detrusor muscle early in the disease that often leads to upstaging and/or lymph node metastasis in many cases at cystectomy. Its association with the usual high-grade urothelial carcinoma provides an easy recognition of malignancy in cytology specimens without attempt at separating or identifying the MPC component. This may be related to our limited familiarity of its cytologic features with only 4 cases described in the literature. We report another case of MPC and highlight its features in cytologic preparations including the presence of singly scattered tumor cells with high nuclear to cytoplasmic ratio and pleomorphic nuclei, clustered cells devoid of fibrovascular core (micropapillae), 3-dimensional cell aggregates, cytoplasmic vacuoles, and micropapillae exhibiting some features of low-grade urothelial neoplasm. Appreciation of these features may help facilitate its early diagnosis and hopefully a better outcome for these aggressive tumors. Diagn. Cytopathol.

Original languageEnglish (US)
Pages (from-to)784-787
Number of pages4
JournalDiagnostic Cytopathology
Volume39
Issue number10
DOIs
StatePublished - Oct 2011

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Urinary Bladder
Carcinoma
Neoplasms
Cystectomy
Vacuoles
Cell Nucleus
Cell Biology
Early Diagnosis
Lymph Nodes
Neoplasm Metastasis
Muscles
Recognition (Psychology)

Keywords

  • cytologic features
  • micropapillary variant
  • urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Micropapillary carcinoma of the urinary bladder : Report of a case and review of its cytologic features. / Nicolas, Marlo M.; Jagirdar, Jaishree S.; Arisco, Amy M.; Valente, Philip T.

In: Diagnostic Cytopathology, Vol. 39, No. 10, 10.2011, p. 784-787.

Research output: Contribution to journalArticle

Nicolas, Marlo M. ; Jagirdar, Jaishree S. ; Arisco, Amy M. ; Valente, Philip T. / Micropapillary carcinoma of the urinary bladder : Report of a case and review of its cytologic features. In: Diagnostic Cytopathology. 2011 ; Vol. 39, No. 10. pp. 784-787.
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