Micronuclei in the peripheral blood and bone marrow cells of rats exposed to 2450 MHz radiofrequency radiation

W. F. Pickard, K. S. Bisht, T. J. Prihoda, M. L. Meltz, M. C. LaRegina, J. L.Roti Roti, W. L. Straube, E. G. Moros

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32 Scopus citations

Abstract

Purpose: To determine the incidence of micronuclei in peripheral blood and bone marrow cells of rats exposed continuously for 24h to 2450 MHz continuous wave radiofrequency radiation (RFR) at an average whole-body specific absorption rate (SAR) of 12 W/kg. Materials and methods: Eight adult male Sprague-Dawley rats were exposed to 2450 MHz RFR in circularly polarized waveguides. Eight sham-exposed rats were kept in similar waveguides without the transmission of RFR. Four rats were treated with mitomycin-C (MMC) and used as positive controls. All rats were necropsied 24 h after the end of RFR and sham exposures, and after the 24 h treatment with MMC. Peripheral blood and bone marrow smears were examined to determine the frequency of micronuclei (MN) in polychromatic erythrocytes (PCE). Results: The results indicated that the incidence of MN/2000 PCE were not significantly different between RFR- and sham-exposed rats. The group mean frequencies of MN in the peripheral blood were 2.3±0.7 in RFR-exposed rats and 2.1±0.6 in sham-exposed rats. In bone marrow cells, the average MN incidence was 3.8±1.0 in RFR-exposed rats and 3.4±0.7 in sham-exposed rats. The corresponding values in positive control rats treated with MMC were 23.5±4.7 in the peripheral blood and 33.8±7.4 in bone marrow cells. Conclusion: There was no evidence for the induction of MN in peripheral blood and bone marrow cells of rats exposed for 24 h to 2450 MHz continuous wave RFR at a whole body average SAR of 12W/kg.

Original languageEnglish (US)
Pages (from-to)1109-1115
Number of pages7
JournalInternational Journal of Radiation Biology
Volume77
Issue number11
DOIs
StatePublished - Nov 15 2001

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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