Micronuclei in peripheral blood and bone marrow cells of mice exposed to 42 GHz electromagnetic millimeter waves

Vijayalaxmi, Mahendra K. Logani, Ashok Bhanushali, Marvin C. Ziskin, Thomas J. Prihoda

Research output: Contribution to journalArticle

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Abstract

The genotoxic potential of 42.2 ± 0.2 GHz electromagnetic millimeter-wave radiation was investigated in adult male BALB/c mice. The radiation was applied to the nasal region of the mice for 30 min/day for 3 consecutive days. The incident power density used was 31.5 ± 5.0 mW/cm2. The peak specific absorption rate was calculated as 622 ± 100 W/kg. Groups of mice that were injected with cyclophosphamide (15 mg/kg body weight), a drug used in the treatment of human malignancies, were also included to determine if millimeter-wave radiation exposure had any influence on drug-induced genotoxicity. Concurrent sham-exposed and untreated mice were used as controls. The extent of genotoxicity was assessed from the incidence of micronuclei in polychromatic erythrocytes of peripheral blood and bone marrow cells collected 24 h after treatment. The results indicated that the incidence of micronuclei in 2000 polychromatic erythrocytes was not significantly different among untreated, millimeter wave-exposed, and sham-exposed mice. The group mean incidences were 6.0 ± 1.6, 5.1 ± 1.5 and 5.1 ± 1.3 in peripheral blood and 9.1 ± 1.1, 9.3 ± 1.6 and 9.1 ± 1.6 in bone marrow cells, respectively. Mice that were injected with cyclophosphamide exhibited significantly increased numbers of micronuclei, 14.6 ± 2.7 in peripheral blood and 21.3 ± 3.9 in bone marrow cells (P < 0.0001). The drug-induced micronuclei were not significantly different in millimeter wave-exposed and sham-exposed mice; the mean incidences were 14.3 ± 2.8 and 15.4 ± 3.0 in peripheral blood and 23.5 ± 2.3 and 22.1 ± 2.5 in bone marrow cells, respectively. Thus there was no evidence for the induction of genotoxicity in the peripheral blood and bone marrow cells of mice exposed to electromagnetic millimeter-wave radiation. Also, millimeter-wave radiation exposure did not influence cyclophosphamide-induced micronuclei in either type of cells.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalRadiation Research
Volume161
Issue number3
DOIs
StatePublished - Mar 2004

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Electromagnetic Radiation
bone marrow
bone marrow cells
Bone Marrow Cells
millimeter waves
blood
mice
electromagnetism
cyclophosphamide
genotoxicity
electromagnetic radiation
incidence
Cyclophosphamide
drugs
Incidence
radiation dosage
erythrocytes
Radiation
Erythrocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Micronuclei in peripheral blood and bone marrow cells of mice exposed to 42 GHz electromagnetic millimeter waves. / Vijayalaxmi; Logani, Mahendra K.; Bhanushali, Ashok; Ziskin, Marvin C.; Prihoda, Thomas J.

In: Radiation Research, Vol. 161, No. 3, 03.2004, p. 341-345.

Research output: Contribution to journalArticle

Vijayalaxmi, Logani, MK, Bhanushali, A, Ziskin, MC & Prihoda, TJ 2004, 'Micronuclei in peripheral blood and bone marrow cells of mice exposed to 42 GHz electromagnetic millimeter waves', Radiation Research, vol. 161, no. 3, pp. 341-345. https://doi.org/10.1667/RR3121
Vijayalaxmi ; Logani, Mahendra K. ; Bhanushali, Ashok ; Ziskin, Marvin C. ; Prihoda, Thomas J. / Micronuclei in peripheral blood and bone marrow cells of mice exposed to 42 GHz electromagnetic millimeter waves. In: Radiation Research. 2004 ; Vol. 161, No. 3. pp. 341-345.
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