Micronuclei in bronchial biopsy specimens from heavy smokers

Characterization of an intermediate marker of lung carcinogenesis

S. E. Benner, S. M. Lippman, Michael J Wargovich, M. Velasco, E. J. Peters, R. C. Morice, W. K. Hong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bronchial micronuclei, small fragments of extra-nuclear DNA formed during cell division, provide a non-specific but quantifiable marker of DNA damage. Micronuclei have been used to assess carcinogen exposure and as an intermediate endpoint in chemoprevention trials. As part of an ongoing chemoprevention trial, heavy smokers underwent screening bronchoscopy, with biopsies taken at 6 standardized sites. Micronuclei counts were obtained for each site in each of the 40 volunteers found to have squamous metaplasia. Unlike squamous metaplasia, the average micronuclei counts among these heavy smokers were not associated with smoking history. Micronuclei counts were also not associated with the presence or extent of metaplasia. A striking degree of intra-individual variability was observed by comparing the micronuclei counts from different biopsy sites within individuals. The findings suggest that use of micronuclei from single sites may be misleading as a marker of carcinogen exposure or as an estimate of cancer risk. Serial measurements in individuals may provide the most useful information concerning carcinogenic exposure and the impact of chemopreventive agents.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalInternational Journal of Cancer
Volume52
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Metaplasia
Carcinogenesis
Chemoprevention
Biopsy
Lung
Bronchoscopy
Tumor Biomarkers
Cell Division
Carcinogens
DNA Damage
Volunteers
Smoking
History
DNA
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Micronuclei in bronchial biopsy specimens from heavy smokers : Characterization of an intermediate marker of lung carcinogenesis. / Benner, S. E.; Lippman, S. M.; Wargovich, Michael J; Velasco, M.; Peters, E. J.; Morice, R. C.; Hong, W. K.

In: International Journal of Cancer, Vol. 52, No. 1, 1992, p. 44-47.

Research output: Contribution to journalArticle

Benner, S. E. ; Lippman, S. M. ; Wargovich, Michael J ; Velasco, M. ; Peters, E. J. ; Morice, R. C. ; Hong, W. K. / Micronuclei in bronchial biopsy specimens from heavy smokers : Characterization of an intermediate marker of lung carcinogenesis. In: International Journal of Cancer. 1992 ; Vol. 52, No. 1. pp. 44-47.
@article{7b7c25fc02544fdc879600e0e2a3b625,
title = "Micronuclei in bronchial biopsy specimens from heavy smokers: Characterization of an intermediate marker of lung carcinogenesis",
abstract = "Bronchial micronuclei, small fragments of extra-nuclear DNA formed during cell division, provide a non-specific but quantifiable marker of DNA damage. Micronuclei have been used to assess carcinogen exposure and as an intermediate endpoint in chemoprevention trials. As part of an ongoing chemoprevention trial, heavy smokers underwent screening bronchoscopy, with biopsies taken at 6 standardized sites. Micronuclei counts were obtained for each site in each of the 40 volunteers found to have squamous metaplasia. Unlike squamous metaplasia, the average micronuclei counts among these heavy smokers were not associated with smoking history. Micronuclei counts were also not associated with the presence or extent of metaplasia. A striking degree of intra-individual variability was observed by comparing the micronuclei counts from different biopsy sites within individuals. The findings suggest that use of micronuclei from single sites may be misleading as a marker of carcinogen exposure or as an estimate of cancer risk. Serial measurements in individuals may provide the most useful information concerning carcinogenic exposure and the impact of chemopreventive agents.",
author = "Benner, {S. E.} and Lippman, {S. M.} and Wargovich, {Michael J} and M. Velasco and Peters, {E. J.} and Morice, {R. C.} and Hong, {W. K.}",
year = "1992",
language = "English (US)",
volume = "52",
pages = "44--47",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Micronuclei in bronchial biopsy specimens from heavy smokers

T2 - Characterization of an intermediate marker of lung carcinogenesis

AU - Benner, S. E.

AU - Lippman, S. M.

AU - Wargovich, Michael J

AU - Velasco, M.

AU - Peters, E. J.

AU - Morice, R. C.

AU - Hong, W. K.

PY - 1992

Y1 - 1992

N2 - Bronchial micronuclei, small fragments of extra-nuclear DNA formed during cell division, provide a non-specific but quantifiable marker of DNA damage. Micronuclei have been used to assess carcinogen exposure and as an intermediate endpoint in chemoprevention trials. As part of an ongoing chemoprevention trial, heavy smokers underwent screening bronchoscopy, with biopsies taken at 6 standardized sites. Micronuclei counts were obtained for each site in each of the 40 volunteers found to have squamous metaplasia. Unlike squamous metaplasia, the average micronuclei counts among these heavy smokers were not associated with smoking history. Micronuclei counts were also not associated with the presence or extent of metaplasia. A striking degree of intra-individual variability was observed by comparing the micronuclei counts from different biopsy sites within individuals. The findings suggest that use of micronuclei from single sites may be misleading as a marker of carcinogen exposure or as an estimate of cancer risk. Serial measurements in individuals may provide the most useful information concerning carcinogenic exposure and the impact of chemopreventive agents.

AB - Bronchial micronuclei, small fragments of extra-nuclear DNA formed during cell division, provide a non-specific but quantifiable marker of DNA damage. Micronuclei have been used to assess carcinogen exposure and as an intermediate endpoint in chemoprevention trials. As part of an ongoing chemoprevention trial, heavy smokers underwent screening bronchoscopy, with biopsies taken at 6 standardized sites. Micronuclei counts were obtained for each site in each of the 40 volunteers found to have squamous metaplasia. Unlike squamous metaplasia, the average micronuclei counts among these heavy smokers were not associated with smoking history. Micronuclei counts were also not associated with the presence or extent of metaplasia. A striking degree of intra-individual variability was observed by comparing the micronuclei counts from different biopsy sites within individuals. The findings suggest that use of micronuclei from single sites may be misleading as a marker of carcinogen exposure or as an estimate of cancer risk. Serial measurements in individuals may provide the most useful information concerning carcinogenic exposure and the impact of chemopreventive agents.

UR - http://www.scopus.com/inward/record.url?scp=0026761932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026761932&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 44

EP - 47

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -