Micromechanical devices for intravascular drug delivery

Michael L. Reed, Clarence Wu, James Kneller, Simon Watkins, David A. Vorp, Ahmed Nadeem, Lee E. Weiss, Keith Rebello, Mark Mescher, A. J. Conrad Smith, Warren Rosenblum, Marc D. Feldman

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Microfabrication technology, more commonly applied to the manufacture of integrated circuits, can be used to build devices useful for mechanical delivery of drugs and genes. Microprobes fabricated using silicon micromachining have been used to deliver DNA into cells as an alternative to bombardment and microinjection. This idea can be extended to intravascular stents with integrated microprobes capable of piercing compressed plaque and delivering anti-restenosis therapies into coronary arteries. Preliminary experiments using filleted rabbit arteries have demonstrated transection of the internal elastic lamina. New nonplanar microfabrication technologies are necessary for creating practical devices with cylindrical symmetry; a promising possibility is to use microfabricated structures of anodic metal oxides.

Original languageEnglish (US)
Pages (from-to)1387-1394
Number of pages8
JournalJournal of Pharmaceutical Sciences
Volume87
Issue number11
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Pharmaceutical Science

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