Microgliosis is associated with visual memory decline in patients with temporal lobe epilepsy and hippocampal sclerosis: A clinicopathologic study

Eliana Cristina de Brito Toscano, Érica Leandro Marciano Vieira, Ana Carolina Diniz Carvalho Portela, Marcelo Vidigal Caliari, Joseane Aparecida Sousa Brant, Alexandre Varella Giannetti, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Ricardo Nitrini, Milene Alvarenga Rachid, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Hippocampal sclerosis (HS) is characterized by neuronal loss and gliosis. The intensity and distribution of these histopathological findings over the Cornu Ammonis (CA) subfields are important for the classification of HS and prognostication of patients with temporal lobe epilepsy (TLE). Several studies have associated the neuronal density reduction in the hippocampus with cognitive decline in patients with TLE. The current study aimed at investigating whether the expression of glial proteins in sclerotic hippocampi is associated with presurgical memory performance of patients with TLE. Before amygdalohippocampectomy, patients were submitted to memory tests. Immunohistochemical and morphometric analyses with glial fibrillary acidic protein (GFAP) for astrogliosis and human leucocyte antigen DR (HLA-DR) for microgliosis were performed in paraffin-embedded HS and control hippocampi. Sclerotic hippocampi exhibited increased gliosis in comparison with controls. In patients with TLE, the area and intensity of staining for HLA-DR were associated with worse performance in the memory tests. Glial fibrillary acidic protein was neither associated nor correlated with memory test performance. Our data suggest association between microgliosis, but not astrogliosis, with visual memory decline in patients with TLE.

Original languageEnglish (US)
Article number106643
JournalEpilepsy and Behavior
Volume102
DOIs
StatePublished - Jan 2020
Externally publishedYes

Keywords

  • Gliosis
  • Hippocampal sclerosis
  • Memory
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Microgliosis is associated with visual memory decline in patients with temporal lobe epilepsy and hippocampal sclerosis: A clinicopathologic study'. Together they form a unique fingerprint.

Cite this