Microglia as mediators of inflammatory and degenerative diseases

F. González-Scarano; Gordon Baltuch

doi:10.1146/annurev.neuro.22.1.219

Microglia as mediators of inflammatory and degenerative diseases

F. González-Scarano, Gordon Baltuch

Neurology

Research output: Contribution to journal › Review article

840 Scopus citations

Abstract

Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

Original language	English (US)
Pages (from-to)	219-240
Number of pages	22
Journal	Annual Review of Neuroscience
Volume	22
DOIs	https://doi.org/10.1146/annurev.neuro.22.1.219
State	Published - Apr 6 1999

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Keywords

Alzheimer's disease
Cytokines
Human immunodeficiency virus
Multiple sclerosis

ASJC Scopus subject areas

Neuroscience(all)

Cite this

González-Scarano, F., & Baltuch, G. (1999). Microglia as mediators of inflammatory and degenerative diseases. Annual Review of Neuroscience, 22, 219-240. https://doi.org/10.1146/annurev.neuro.22.1.219

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10.1146/annurev.neuro.22.1.219