Microglia as mediators of inflammatory and degenerative diseases

F. González-Scarano, Gordon Baltuch

Research output: Contribution to journalReview article

840 Scopus citations

Abstract

Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)219-240
Number of pages22
JournalAnnual Review of Neuroscience
Volume22
DOIs
StatePublished - Apr 6 1999

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Keywords

  • Alzheimer's disease
  • Cytokines
  • Human immunodeficiency virus
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)

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