TY - JOUR
T1 - Microglia as mediators of inflammatory and degenerative diseases
AU - González-Scarano, F.
AU - Baltuch, Gordon
PY - 1999
Y1 - 1999
N2 - Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.
AB - Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.
KW - Alzheimer's disease
KW - Cytokines
KW - Human immunodeficiency virus
KW - Multiple sclerosis
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U2 - 10.1146/annurev.neuro.22.1.219
DO - 10.1146/annurev.neuro.22.1.219
M3 - Review article
C2 - 10202538
AN - SCOPUS:0032942060
VL - 22
SP - 219
EP - 240
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
SN - 0147-006X
ER -