Abstract
Percutaneous coronary intervention is currently used to treat coronary atherosclerosis but is plagued by restenosis. The atherosclerotic plaque acts as a barrier, preventing the delivery of drugs or gene therapy to prevent restenosis. We hypothesize that microfabricated probes, manufactured using silicon fabrication technology, can penetrate through atherosclerotic plaque, creating paths for therapeutic delivery. Two sets of microfabricated probes (65 ± 15 and 140 ± 20 μm) were deployed in normal and atherosclerotic rabbit iliac artery segments (n=5 each) under distention pressures of 100, 200, 300, and 500 mmHg, to simulate deployed stents. The tissues were fixed while the probes remained in place and analyzed using standard SEM, TEM and light microscopy techniques to evaluate the extent and nature of vessel penetration. In healthy tissue, microprobes are able to pierce the internal elastic lamina and penetrate the media, with the highest probes nearly reaching the media/adventitia boundary. Atherosclerotic plaque is pierced by microprobes at all intraluminal pressures examined. These results indicate that microprobes may serve as a technique to penetrate the atherosclerotic plaque for the purpose of delivering therapeutics beyond the plaque.
| Original language | English (US) |
|---|---|
| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Publisher | IEEE |
| Pages | 2277-2280 |
| Number of pages | 4 |
| Volume | 5 |
| State | Published - 1997 |
| Externally published | Yes |
| Event | Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA Duration: Oct 30 1997 → Nov 2 1997 |
Other
| Other | Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
|---|---|
| City | Chicago, IL, USA |
| Period | 10/30/97 → 11/2/97 |
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ASJC Scopus subject areas
- Bioengineering
Cite this
Microfabricated device for arterial wall and atherosclerotic plaque penetration. / Kneller, James R.; Wu, Clarence C.; Watkins, Simon; Nadeem, Ahmed; Reed, Michael; Weiss, Lee; Feldman, Marc D.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5 IEEE, 1997. p. 2277-2280.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Microfabricated device for arterial wall and atherosclerotic plaque penetration
AU - Kneller, James R.
AU - Wu, Clarence C.
AU - Watkins, Simon
AU - Nadeem, Ahmed
AU - Reed, Michael
AU - Weiss, Lee
AU - Feldman, Marc D
PY - 1997
Y1 - 1997
N2 - Percutaneous coronary intervention is currently used to treat coronary atherosclerosis but is plagued by restenosis. The atherosclerotic plaque acts as a barrier, preventing the delivery of drugs or gene therapy to prevent restenosis. We hypothesize that microfabricated probes, manufactured using silicon fabrication technology, can penetrate through atherosclerotic plaque, creating paths for therapeutic delivery. Two sets of microfabricated probes (65 ± 15 and 140 ± 20 μm) were deployed in normal and atherosclerotic rabbit iliac artery segments (n=5 each) under distention pressures of 100, 200, 300, and 500 mmHg, to simulate deployed stents. The tissues were fixed while the probes remained in place and analyzed using standard SEM, TEM and light microscopy techniques to evaluate the extent and nature of vessel penetration. In healthy tissue, microprobes are able to pierce the internal elastic lamina and penetrate the media, with the highest probes nearly reaching the media/adventitia boundary. Atherosclerotic plaque is pierced by microprobes at all intraluminal pressures examined. These results indicate that microprobes may serve as a technique to penetrate the atherosclerotic plaque for the purpose of delivering therapeutics beyond the plaque.
AB - Percutaneous coronary intervention is currently used to treat coronary atherosclerosis but is plagued by restenosis. The atherosclerotic plaque acts as a barrier, preventing the delivery of drugs or gene therapy to prevent restenosis. We hypothesize that microfabricated probes, manufactured using silicon fabrication technology, can penetrate through atherosclerotic plaque, creating paths for therapeutic delivery. Two sets of microfabricated probes (65 ± 15 and 140 ± 20 μm) were deployed in normal and atherosclerotic rabbit iliac artery segments (n=5 each) under distention pressures of 100, 200, 300, and 500 mmHg, to simulate deployed stents. The tissues were fixed while the probes remained in place and analyzed using standard SEM, TEM and light microscopy techniques to evaluate the extent and nature of vessel penetration. In healthy tissue, microprobes are able to pierce the internal elastic lamina and penetrate the media, with the highest probes nearly reaching the media/adventitia boundary. Atherosclerotic plaque is pierced by microprobes at all intraluminal pressures examined. These results indicate that microprobes may serve as a technique to penetrate the atherosclerotic plaque for the purpose of delivering therapeutics beyond the plaque.
UR - http://www.scopus.com/inward/record.url?scp=0031294870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031294870&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:0031294870
VL - 5
SP - 2277
EP - 2280
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
ER -