Microevolution and virulence of dengue viruses

Rebeca Rico-Hesse

Research output: Chapter in Book/Report/Conference proceedingChapter

271 Scopus citations

Abstract

The evolution of dengue viruses has had a major impact on their virulence for humans and on the epidemiology of dengue disease around the world. Although antigenic and genetic differences in virus strains had become evident, it is mainly due to the lack of animal models of disease that has made it difficult to detect differences in virulence of dengue viruses. However, phylogenetic studies of many different dengue virus samples have led to the association between specific genotypes (within serotypes) and the presentation of more or less severe disease. Currently, dengue viruses can be classified as being of epidemiologically low, medium, or high impact; i.e., some viruses may remain in sylvatic cycles of little or low transmissibility to humans, others produce dengue fever (DF) only, and some genotypes have been associated with the potential to cause the more severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in addition to DF. Although the factors that contribute to dengue virus epidemiology are complex, studies have suggested that specific viral structures may contribute to increased replication in human target cells and to increased transmission by the mosquito vector; however, the immune status and possibly the genetic background of the host are also determinants of virulence or disease presentation. As to the question of whether dengue viruses are evolving toward virulence as they continue to spread throughout the world, phylogenetic and epidemiological analyses suggest that the more virulent genotypes are now displacing those that have lower epidemiological impact; there is no evidence for the transmission of antigenically aberrant, new strains.

Original languageEnglish (US)
Title of host publicationAdvances in Virus Research
PublisherAcademic Press Inc.
Pages315-341
Number of pages27
ISBN (Print)0120398591, 9780120398591
DOIs
StatePublished - 2003
Externally publishedYes

Publication series

NameAdvances in Virus Research
Volume59
ISSN (Print)0065-3527
ISSN (Electronic)1557-8399

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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