TY - JOUR
T1 - Microbiota impact on the epigenetic regulation of colorectal cancer
AU - Yang, Tao
AU - Owen, Jennifer L.
AU - Lightfoot, Yaíma L.
AU - Kladde, Michael P.
AU - Mohamadzadeh, Mansour
N1 - Funding Information:
This work was supported in part by National Institutes of Health (NIH) grant 1R01AI098833-01, Department of Defense (DoD) grant CA111002, Gatorade Trust Pilot Project Funding from the University of Florida, and NIH/National Center for Research Resources (NCRR) Clinical and Translational Science Award to the University of Florida (UL1 RR 029890).
PY - 2013/12
Y1 - 2013/12
N2 - Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed 'dysbiosis', has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore may be amenable to therapeutic intervention.
AB - Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed 'dysbiosis', has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore may be amenable to therapeutic intervention.
KW - Colorectal cancer
KW - Commensal bacteria
KW - Epigenetic regulation
KW - Inflammatory bowel disease
KW - Microbiota
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U2 - 10.1016/j.molmed.2013.08.005
DO - 10.1016/j.molmed.2013.08.005
M3 - Review article
C2 - 24051204
AN - SCOPUS:84888435366
SN - 1471-4914
VL - 19
SP - 714
EP - 725
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 12
ER -