Microbiota impact on the epigenetic regulation of colorectal cancer

Tao Yang, Jennifer L. Owen, Yaíma L. Lightfoot, Michael P. Kladde, Mansour Mohamadzadeh

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed 'dysbiosis', has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore may be amenable to therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)714-725
Number of pages12
JournalTrends in Molecular Medicine
Volume19
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Colorectal cancer
  • Commensal bacteria
  • Epigenetic regulation
  • Inflammatory bowel disease
  • Microbiota

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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