TY - JOUR
T1 - Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients
AU - Westbrook, Steven D.
AU - Kirkpatrick, William R.
AU - Wiederhold, Nathan P.
AU - Freytes, Cesar O.
AU - Toro, Juan J.
AU - Patterson, Thomas F.
AU - Redding, Spencer W.
N1 - Funding Information:
The authors thank Marcos Olivo for his technical assistance with yeast identification and isolation. We are grateful to the Fungus Testing Laboratory of the University of Texas Health Science Center at San Antonio for their assistance in determining the MICs of the yeast isolates. This work was supported in part by Public Health Service Grant DE-18096 from the National Institute of Dental and Craniofacial Research .
PY - 2013/3
Y1 - 2013/3
N2 - Objective: We monitored the epidemiology and microbiology of oral yeast colonization in patients undergoing hemopoietic progenitor cell transplantation (HPCT) to examine associations between yeast colonization and oral mucositis. Study Design: One hundred twenty-one consecutive HPCT patients were sampled for oral yeasts prior to fluconazole (FLC) prophylaxis, at transplantation, and weekly until discharge. Clinical oral mucositis screenings were performed triweekly. Results: Yeast colonization was evident at 216 of 510 total visits. Candida albicans and Candida glabrata were the predominant organisms. Eight patients showed elevated minimal inhibitory concentrations to FLC. One patient developed fungal septicemia. Patients with oral mucositis assessment scale scores <20 had higher colonization rates than those with higher scores. Conclusions: FLC is effective in controlling a variety of oral yeasts in HPCT recipients. FLC-resistant yeasts do emerge and can be the source of fungal sepsis. A positive association was not shown between yeast colonization and the presence or severity of oral mucositis.
AB - Objective: We monitored the epidemiology and microbiology of oral yeast colonization in patients undergoing hemopoietic progenitor cell transplantation (HPCT) to examine associations between yeast colonization and oral mucositis. Study Design: One hundred twenty-one consecutive HPCT patients were sampled for oral yeasts prior to fluconazole (FLC) prophylaxis, at transplantation, and weekly until discharge. Clinical oral mucositis screenings were performed triweekly. Results: Yeast colonization was evident at 216 of 510 total visits. Candida albicans and Candida glabrata were the predominant organisms. Eight patients showed elevated minimal inhibitory concentrations to FLC. One patient developed fungal septicemia. Patients with oral mucositis assessment scale scores <20 had higher colonization rates than those with higher scores. Conclusions: FLC is effective in controlling a variety of oral yeasts in HPCT recipients. FLC-resistant yeasts do emerge and can be the source of fungal sepsis. A positive association was not shown between yeast colonization and the presence or severity of oral mucositis.
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U2 - 10.1016/j.oooo.2012.10.012
DO - 10.1016/j.oooo.2012.10.012
M3 - Article
C2 - 23312542
AN - SCOPUS:84875382817
SN - 2212-4403
VL - 115
SP - 354
EP - 358
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 3
ER -