Microarray profile of human kidney from diabetes, renal cell carcinoma and renal cell carcinoma with diabetes

Adam Kosti, Hung I Harry Chen, Sumathy Mohan, Sitai Liang, Yidong Chen, Samy L Habib

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Recent study from our laboratory showed that patients with diabetes are at a higher risk of developing kidney cancer. In the current study, we have screened whole human DNA genome from healthy control, patients with diabetes or renal cell carcinoma (RCC) or RCC+diabetes. We found that 883 genes gain/163 genes loss of copy number in RCC+diabetes group, 669 genes gain/307 genes loss in RCC group and 458 genes gain/38 genes loss of copy number in diabetes group, after removing gain/loss genes obtained from healthy control group. Data analyzed for functional annotation enrichment pathways showed that control group had the highest number (280) of enriched pathways, 191 in diabetes+RCC group, 148 in RCC group, and 81 in diabetes group. The overlap GO pathways between RCC+diabetes and RCC groups showed that nine were enriched, between RCC+diabetes and diabetes groups was four and between diabetes and RCC groups was eight GO pathways. Overall, we observed majority of DNA alterations in patients from RCC+diabetes group. Interestingly, insulin receptor (INSR) is highly expressed and had gains in copy number in RCC+diabetes and diabetes groups. The changes in INSR copy number may use as a biomarker for predicting RCC development in diabetic patients.

Original languageEnglish (US)
Pages (from-to)62-70
Number of pages9
JournalGenes and Cancer
Volume6
Issue number1-2
StatePublished - 2015

Keywords

  • Diabetes
  • Microarray
  • RCC
  • Renal

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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