Microarray image analysis and gene expression ratio statistics

Yidong Chen, Edward R. Dougherty, Michael L. Bittner, Paul Meltzer, Jeffery Trent

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

4. Conclusions: Various image analysis issues have been addressed: target segmentation, background detection, target detection, and intensity measurement. Since microarray technology is still under development and image quality varies considerably, a robust and precise image analysis algorithm that reduces background interference and extracts precise signal intensity and expression ratios for each gene is critical to the success of further statistical analysis. The overall methodology discussed in this chapter has been developed and enhanced through five years of experience working with cDNA microarray images. It continues to be expanded and revised as new issues arise.

Original languageEnglish (US)
Title of host publicationComputational and Statistical Approaches to Genomics
PublisherSpringer US
Pages1-19
Number of pages19
Volume9780387262871
ISBN (Electronic)9780387262888
ISBN (Print)0387262873, 9780387262871
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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